Ethambutol Dosage

Generic name: ethambutol
Brand name: Myambutol
Drug class: Miscellaneous antituberculosis agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 100 mg, 400 mg

Tuberculosis, active

[40-55 kg]

Dose: 800 mg PO qd; Alt: 800 mg PO 5x/wk if directly observed tx; 1200 mg PO 3x/wk or 2000 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

[56-75 kg]

Dose: 1200 mg PO qd; Alt: 1200 mg PO 5x/wk if directly observed tx; 2000 mg PO 3x/wk or 2800 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

[76-90 kg]

Dose: 1600 mg PO qd: Alt: 1600 mg PO 5x/wk if directly observed tx; 2400 mg PO 3x/wk or 4000 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

MAC tx, disseminated

[15 mg/kg/dose PO qd]

Info: use w/ clarithromycin or azithromycin

MAC prophylaxis, secondary

[15 mg/kg/dose PO qd]

Info: use w/ clarithromycin or azithromycin

Renal dosing

[adjust dose frequency]

CrCl <30: 15-25 mg/kg/dose 3x/wk

HD: 15-25 mg/kg/dose 3x/wk after dialysis; no supplement; PD: 15-25 mg/kg/dose 3x/wk; no supplement

Hepatic dosing

[not defined]

Recommended Peds  Dosing

Dosage forms:  TAB: 100 mg, 400 mg

Tuberculosis, active

[<5 yo]

Dose: 15-25 mg/kg/dose PO qd; Max: 1000 mg/day; Alt: 15-25 mg/kg/dose PO 5x/wk if directly observed tx; Info: part of multi-drug regimen; only for isoniazid or rifampin resistance

[5 yo and older, <40 kg]

Dose: 15-25 mg/kg/dose PO qd; Max: 1000 mg/day; Alt: 15-25 mg/kg/dose PO 5x/wk if directly observed tx; 50 mg/kg/dose PO 2x/wk if directly observed tx, max 2500 mg/dose; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

[5 yo and older, 40-55 kg]

Dose: 800 mg PO qd; Alt: 800 mg PO 5x/wk if directly observed tx; 1200 mg PO 3x/wk or 2000 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

[5 yo and older, 56-75 kg]

Dose: 1200 mg PO qd; Alt: 1200 mg PO 5x/wk if directly observed tx; 2000 mg PO 3x/wk or 2800 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

[5 yo and older, 76-90 kg]

Dose: 1600 mg PO qd: Alt: 1600 mg PO 5x/wk if directly observed tx; 2400 mg PO 3x/wk or 4000 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen

MAC tx, disseminated

[1 mo-12 yo]

Dose: 15-25 mg/kg/dose PO qd; Max: 2500 mg/day; Info: use w/ clarithromycin or azithromycin

[13 yo and older]

Dose: 15 mg/kg/dose PO qd; Info: use w/ clarithromycin or azithromycin

MAC prophylaxis, secondary

[1 mo-12 yo]

Dose: 15-25 mg/kg/dose PO qd; Max: 2500 mg/day; Info: use w/ clarithromycin or azithromycin

[13 yo and older]

Dose: 15 mg/kg/dose PO qd; Info: use w/ clarithromycin or azithromycin

Renal dosing

[adjust dose frequency]

CrCl 10-50: 15-25 mg/kg/dose q24-36h; CrCl <10: 15-25 mg/kg/dose q48h

HD: 15-25 mg/kg/dose 3x/wk after dialysis; no supplement; PD: 15-25 mg/kg/dose 3x/wk; no supplement

Hepatic dosing

[not defined]

SRC: NLM .