Ertapenem

Generic name: ertapenem
Brand names: INVanz, INVanz ADD-Vantage
Dosage form: injectable powder for injection (1 g)
Drug class: Carbapenems

Medically reviewed by  A Ras MD.

What is ertapenem?

Ertapenem is a prescription medicine that is used to treat or prevent bacterial infections. Ertapenem for injection is a sterile, synthetic, parenteral, 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics.

Description

Chemically, Ertapenem for injection is described as [4R-[3(3S*,5S*),4α,5β,6β(R*)]]-3-[[5-[[(3­carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1­ azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt. Its molecular weight is 497.50. The empirical formula is C 222437SNa, and its structural formula is:

 

Chemcial Structure

Ertapenem sodium is a white to off-white hygroscopic, weakly crystalline powder. It is soluble in water and 0.9% sodium chloride solution, practically insoluble in ethanol, and insoluble in isopropyl acetate and tetrahydrofuran.

Ertapenem for injection is supplied as sterile lyophilized powder for intravenous infusion after reconstitution with appropriate diluent and transfer to 50 mL 0.9% Sodium Chloride Injection or for intramuscular injection following reconstitution with 1% lidocaine hydrochloride. Each single-dose vial contains 1 gram ertapenem equivalent to 1.046 grams ertapenem sodium. The sodium content is approximately 137 mg (approximately 6.0 mEq).

Each vial of Ertapenem for injection contains the following inactive ingredients: 175 mg sodium bicarbonate and sodium hydroxide to adjust pH to 7.5

Before taking ertapenem, tell your doctor:

  • If you are allergic to ertapenem; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you are taking any of these drugs: Divalproex or valproic acid.
  • If you are taking probenecid.

This is not a list of all drugs or health problems that interact with ertapenem.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take ertapenem with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take ertapenem?

  • Tell all of your health care providers that you take ertapenem. This includes your doctors, nurses, pharmacists, and dentists.
  • Have your blood work checked if you are on ertapenem for a long time. Talk with your doctor.
  • Do not use longer than you have been told. A second infection may happen.
  • Severe and sometimes deadly allergic side effects have rarely happened with drugs like this one.
  • Do not give ertapenem to a child younger than 3 months of age.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is ertapenem best taken?

Use ertapenem as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into a muscle or as an infusion into a vein over a period of time.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are the side effects of ertapenem that I need to call my doctor about immediately?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Feeling agitated.
  • Feeling confused.
  • Feeling very tired or weak.
  • Mood changes.
  • Seizures.
  • Shakiness.
  • Trouble controlling body movements.
  • Feeling very sleepy.
  • Diarrhea is common with antibiotics. Rarely, a severe form called C diff–associated diarrhea (CDAD) may happen. Sometimes, this has led to a deadly bowel problem (colitis). CDAD may happen during or a few months after taking antibiotics. Call your doctor right away if you have stomach pain, cramps, or very loose, watery, or bloody stools. Check with your doctor before treating diarrhea.

What are some other side effects of ertapenem?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Upset stomach or throwing up.
  • Diarrhea.
  • Headache.
  • Irritation where ertapenem is given.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If overdose is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out ertapenem?

  • If you need to store ertapenem at home, talk with your doctor, nurse, or pharmacist about how to store it.

 

Label

PRINCIPAL DISPLAY PANEL – 1 G VIAL LABEL

  • NDC 60505-6196-0
  • Ertapenemfor Injection
  • 1 gram/vial
  • For Intravenousor Intramuscular Use
  • Rx only
  • Ertapenem

PRINCIPAL DISPLAY PANEL – 10 VIAL CARTON

 

  • NDC 60505-6196-4
  • Ertapenem for Injection
  • 1 gram/vial
  • For Intravenous Or Intramuscular Use
  • x Only
  • 10 x 1 g Single dose vialsEach vial contains:

    1.046 grams ertapenem sodium, equiv. to 1 gram ertapenem.Prior to Constitution: Store lyophilized powder below 25°C (77°F).

Carton label

SRC: NLM .