Eplerenone Dosage
Generic name: eplerenone
Brand name: Inspra
Drug classes: Aldosterone receptor antagonists, Potassium-sparing diuretics
Recommended Adult Dosing
Dosage forms: TAB: 25 mg, 50 mg
Heart failure w/ reduced ejection fraction, post-MI
- [50 mg PO qd]
- Start: 25 mg PO qd, incr. to 50 mg PO qd after 4wk; Max: 50 mg/day; Info: see pkg insert for dose adjustments based on potassium levels
HTN
- [50 mg PO qd-bid]
- Start: 50 mg PO qd, may incr. to 50 mg PO bid after 4wk; Max: 100 mg/day
Renal dosing
- [heart failure w/ reduced ejection fraction, post-MI]
- eGFR 31-49: start 25 mg qod, may incr. to 25 mg qd after 4wk, max 25 mg/day; eGFR or CrCl <31: avoid use
- HD/PD: not defined
- [HTN]
- Cr >2 (males) or >1.8 (females), CrCl <50: contraindicated
- HD/PD: not defined
Hepatic dosing
- mild-mod impairment: no adjustment; severe impairment: not defined
SRC: NLM .