Epivir-HBV Dosage

Generic name: lamivudine
Dosage form: tablet, film coated and oral solution
Drug class: Nucleoside reverse transcriptase inhibitors (NRTIs)

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 100 mg; SOL: 5 mg per mL

Hepatitis B infection, chronic

[100 mg PO qd]

Info: higher doses required for pts w/ HIV co-infection

Hepatitis B infection prophylaxis, perinatal transmission

[100 mg PO qd]

Start: at 28-32 wk gestation; Info: for pregnant pts w/ HBV DNA >200,000; not 1st-line agent; D/C between birth to 3mo postpartum

Renal dosing

CrCl 30-49: 100 mg x1, then 50 mg solution qd; CrCl 15-29: 100 mg x1, then 25 mg solution qd; CrCl 5-14: 35 mg solution x1, then 15 mg solution qd; CrCl <5: 35 mg solution x1, then 10 mg solution qd

HD: 35 mg solution x1, then 10-15 mg solution qd; no supplement; PD: not defined

Hepatic dosing

hepatic impairment: no adjustment; decompensated hepatic dz: not defined

Recommended Peds Dosing

Dosage forms:  TAB: 100 mg; SOL: 5 mg per mL

Hepatitis B infection, chronic

[2 yo and older]

Dose: 3 mg/kg/dose PO qd; Max: 100 mg/day; Info: higher doses required for pts w/ HIV co-infection

Hepatitis B infection prophylaxis, perinatal transmission

[100 mg PO qd]

Start: at 28-32 wk gestation; Info: for pregnant pts w/ HBV DNA >200,000; not 1st-line agent; D/C between birth to 3mo postpartum

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

Hepatic dosing

hepatic impairment: no adjustment; decompensated hepatic dz: not defined

SRC: NLM .