Epclusa Dosage

Generic name: sofosbuvir and velpatasvir
Drug class: Antiviral combinations

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 200 mg/50 mg, 400 mg/100 mg; PELLET: 150 mg/37.5 mg per pkt, 200 mg/50 mg per pkt

Chronic hepatitis C infection, genotypes 1-6

[pts w/o cirrhosis or w/ compensated cirrhosis]

Dose: 400 mg/100 mg PO qd x12wk; Info: may give w/ ribavirin in pts w/ genotype 3; refer to AASLD/IDSA hepatitis C guidelines; do not chew pellets

[pts w/ decompensated cirrhosis]

Dose: 400 mg/100 mg PO qd x12wk or x24wk; Info: may give w/ ribavirin; duration depends on ribavirin eligibility, prior tx, liver transplant status; refer to AASLD/IDSA hepatitis C guidelines; do not chew pellets

Renal dosing

[pts w/o cirrhosis or w/ compensated cirrhosis]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

[pts w/ decompensated cirrhosis]

mild-moderate impairment: no adjustment; severe impairment: not defined

HD/PD: not defined

Hepatic dosing

[no adjustment]

SRC: NLM .