Entrectinib Dosage
Generic name: entrectinib
Brand name: Rozlytrek
Dosage form: oral capsule (100 mg; 200 mg)
Drug class: Multikinase inhibitors
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: CAP: 100 mg, 200 mg
Non-small cell lung CA, metastatic
- [600 mg PO qd]
- Info: for pts w/ ROS1-positive dz; do not open/crush/chew/dissolve cap
Neurotrophic receptor tyrosine kinase (NTRK) gene fusion-positive solid tumors, metastatic or unresectable
- [600 mg PO qd]
- Info: for refractory dz; do not open/crush/chew/dissolve cap
Renal dosing
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
Hepatic dosing
- bilirubin 1-1.5x ULN: no adjustment; bilirubin >1.5x ULN: not defined
Recommended Peds Dosing
- Dosage forms: CAP: 100 mg, 200 mg
Neurotrophic receptor tyrosine kinase (NTRK) gene fusion-positive solid tumors, metastatic or unresectable
- [12 yo and older, BSA 0.91-1.1 m^2]
- Dose: 400 mg PO qd; Info: for refractory dz; do not open/crush/chew/dissolve cap
- [12 yo and older, BSA 1.11-1.5 m^2]
- Dose: 500 mg PO qd; Info: for refractory dz; do not open/crush/chew/dissolve cap
- [12 yo and older, BSA >1.5 m^2]
- Dose: 600 mg PO qd; Info: for refractory dz; do not open/crush/chew/dissolve cap
Renal dosing
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
Hepatic dosing
- bilirubin 1-1.5x ULN: no adjustment; bilirubin >1.5x ULN: not defined
SRC: NLM .