Jump To

Enhertu Dosage

Generic name: fam-trastuzumab deruxtecan
Dosage form: intravenous infusion
Drug class: HER2 inhibitors

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  INJ

HER2-overexpressing breast CA, unresectable or metastatic

[5.4 mg/kg/dose IV x1 on day 1 of 21-day cycle]
Info: for pts who have received a prior anti-HER2-based regimen

HER2-low breast CA, unresectable or metastatic

[5.4 mg/kg/dose IV x1 on day 1 of 21-day cycle]
Info: for pts w/ IHC1+ or IHC2+/ISH-negative dz who have received prior tx

HER2-mutant non-small cell lung CA, unresectable or metastatic

[5.4 mg/kg/dose IV x1 on day 1 of 21-day cycle]
Info: for pts w/ activating HER2 (ERBB2) mutations who have received prior tx

HER2-overexpressing gastric CA, locally advanced or metastatic

[6.4 mg/kg/dose IV x1 on day 1 of 21-day cycle]
Info: for pts w/ gastric or gastroesophageal junction adenocarcinoma who have received a prior trastuzumab-based regimen

Renal dosing

CrCl >30: no adjustment; CrCl <30: not defined
HD/PD: not defined

Hepatic dosing

bilirubin 1-3x ULN or AST >ULN: no adjustment; bilirubin >3x ULN and any AST: not defined

 

SRC: NLM .

Read Next Article

PHP Code Snippets Powered By : XYZScripts.com