Enhertu Dosage
Generic name: fam-trastuzumab deruxtecan
Dosage form: intravenous infusion
Drug class: HER2 inhibitors
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
HER2-overexpressing breast CA, unresectable or metastatic
- [5.4 mg/kg/dose IV x1 on day 1 of 21-day cycle]
- Info: for pts who have received a prior anti-HER2-based regimen
HER2-low breast CA, unresectable or metastatic
- [5.4 mg/kg/dose IV x1 on day 1 of 21-day cycle]
- Info: for pts w/ IHC1+ or IHC2+/ISH-negative dz who have received prior tx
HER2-mutant non-small cell lung CA, unresectable or metastatic
- [5.4 mg/kg/dose IV x1 on day 1 of 21-day cycle]
- Info: for pts w/ activating HER2 (ERBB2) mutations who have received prior tx
HER2-overexpressing gastric CA, locally advanced or metastatic
- [6.4 mg/kg/dose IV x1 on day 1 of 21-day cycle]
- Info: for pts w/ gastric or gastroesophageal junction adenocarcinoma who have received a prior trastuzumab-based regimen
Renal dosing
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
Hepatic dosing
- bilirubin 1-3x ULN or AST >ULN: no adjustment; bilirubin >3x ULN and any AST: not defined
SRC: NLM .