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Empaveli Dosage

Generic name: pegcetacoplan
Dosage form: injection, for subcutaneous use
Drug class: Selective immunosuppressants

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  INJ

Restricted Distribution in US

[1-888-343-7073 or www.empavelirems.com for more info]

Paroxysmal nocturnal hemoglobinuria

[1080 mg SC 2x/wk]
Info: give meningococcal, pneumococcal and haemophilus b vaccines >2wk before tx per ACIP guidelines, or give 2wk antibacterial prophylaxis if tx must start w/in 2wk of vaccination; when switching from eculizumab, initiate 1st pegcetacoplan dose 4wk before D/C eculizumab; when switching from ravulizumab, initiate 1st pegcetacoplan dose w/in 4wk after last ravulizumab dose; incr. dose to 1080 mg SC q3 days if LDH >2x ULN, then monitor LDH 2x/wk for at least 4wk

Renal dosing

renal impairment: no adjustment
HD/PD: not defined

Hepatic dosing

[no adjustment]

 

 

SRC: NLM .

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