Emend Dosage

Generic name: aprepitant (oral/injection)
Drug class: NK1 receptor antagonists

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  CAP: 80 mg, 125 mg; SUSP: 25 mg per mL

Nausea/vomiting prevention, chemo-related

[125 mg PO x1 on day 1, then 80 mg PO qam on days 2-3]
Start: 1h before chemo on day 1; Info: give w/ corticosteroid and 5-HT3 antagonist

*Nausea/vomiting prevention, postop

[40 mg PO x1]
Start: 3h before anesthesia induction

Renal dosing

renal impairment: no adjustment
HD: no adjustment; no supplement; PD: not defined

Hepatic dosing

[see below]
Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Recommended Peds Dosing

Dosage forms:  CAP: 80 mg, 125 mg; SUSP: 25 mg per mL

Nausea/vomiting prevention, chemo-related

[oral susp, 6 mo and older, >6 kg]
Dose: 3 mg/kg/dose PO x1 on day 1, then 2 mg/kg/dose PO qam on days 2-3; Start: 1h before chemo on day 1; Max: 125 mg on day 1, 80 mg/day on days 2-3; Info: give w/ 5-HT3 antagonist and w/ or w/o corticosteroid
[oral cap, 12 yo and older]
Dose: 125 mg PO x1 on day 1, then 80 mg PO qam on days 2-3; Start: 1h before chemo on day 1; Info: give w/ corticosteroid and 5-HT3 antagonist

Renal dosing

[see below]
renal impairment: no adjustment
HD: no adjustment; no supplement; PD: not defined

Hepatic dosing

[see below]
Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

 

SRC: NLM .