Eliglustat Dosage

Generic name: eliglustat
Brand name: Cerdelga
Drug class: Miscellaneous metabolic agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 84 mg

Gaucher disease, type 1

[extensive CYP2D6 metabolizer]

Dose: 84 mg PO bid; Info: if switching from another enzyme replacement tx, start w/ previous enzyme replacement dose 24h after last admin; do not open/dissolve cap

[intermediate CYP2D6 metabolizer]

Dose: 84 mg PO bid; Info: if switching from another enzyme replacement tx, start w/ previous enzyme replacement dose 24h after last admin; do not open/dissolve cap

[poor CYP2D6 metabolizer]

Dose: 84 mg PO qd; Info: if switching from another enzyme replacement tx, start w/ previous enzyme replacement dose 24h after last admin; do not open/dissolve cap

Renal dosing

[extensive CYP2D6 metabolizer]

CrCl <15: avoid use

HD/PD: avoid use

[intermediate or poor CYP2D6 metabolizer]

renal impairment: avoid use

HD/PD: avoid use

Hepatic dosing

[extensive CYP2D6 metabolizer]

Child-Pugh Class A: recommendations may vary based on concomitant drugs, see drug interactions; Child-Pugh Class B or C: contraindicated

[intermediate CYP2D6 metabolizer]

hepatic impairment: contraindicated

[poor CYP2D6 metabolizer]

hepatic impairment: contraindicated

SRC: NLM .