Elapegademase Dosage

Generic name: elapegademase
Brand name: Revcovi
Drug class: Other immunostimulants

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ: 2.4 mg per 1.5 mL

Adenosine deaminase severe combined immune deficiency

[pegademase bovine tx-naive pts]
Dose: individualize dose IM divided 2x/wk; Start: 0.4 mg/kg/dose IM divided 2x/wk for at least 12-24wk until immune reconstitution is achieved; Info: use ABW or IBW, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution
[conversion from pegademase bovine, dose unknown or <30 units/kg/wk]
Dose: individualize dose IM divided by the desired number of doses per wk; Start: 0.2 mg/kg/dose IM qwk, then may incr. dose by 0.033 mg/kg/wk; Info: use ABW or IBW, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution
[conversion from pegademase bovine, dose >30 units/kg/wk]
Dose: individualize dose IM divided by the desired number of doses per wk; Start: weekly IM dose (mg/kg/dose) = [last pegademase bovine dose (units/kg)] divided by 150, then may incr. dose by 0.033 mg/kg/wk; Info: use ABW or IBW, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution

Renal dosing

[not defined]
renal impairment: not defined
HD/PD: not defined

Hepatic dosing

[not defined]

Recommended Adult Dosing

Dosage forms:  INJ: 2.4 mg per 1.5 mL

Adenosine deaminase severe combined immune deficiency

[pegademase bovine tx-naive pts]
Dose: individualize dose IM divided 2x/wk; Start: 0.4 mg/kg/dose IM divided 2x/wk for at least 12-24wk until immune reconstitution is achieved; Info: use ABW or IBW, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution
[conversion from pegademase bovine, dose unknown or <30 units/kg/wk]
Dose: individualize dose IM divided by the desired number of doses per wk; Start: 0.2 mg/kg/dose IM qwk, then may incr. dose by 0.033 mg/kg/wk; Info: use ABW or IBW, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution
[conversion from pegademase bovine, dose >30 units/kg/wk]
Dose: individualize dose IM divided by the desired number of doses per wk; Start: weekly IM dose (mg/kg/dose) = [last pegademase bovine dose (units/kg)] divided by 150, then may incr. dose by 0.033 mg/kg/wk; Info: use ABW or IBW, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution

Renal dosing

[not defined]
renal impairment: not defined
HD/PD: not defined

Hepatic dosing

[not defined]
SRC: NLM .