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Durvalumab Dosage

Generic name: durvalumab
Brand name: Imfinzi
Drug class: Anti-PD-1 monoclonal antibodies

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Restricted Distribution in US

[1-844-275-2360 or www.imfinzi.com for more info]

Stage III non-small cell lung CA, unresectable

[10 mg/kg/dose IV q2wk for up to 12mo]
Alt: 1500 mg IV q4wk for up to 12mo if wt >30 kg; Info: for non-progressive dz after concurrent platinum-based chemo and XRT

Extensive-stage small cell lung CA, first-line tx

[>30 kg]
Dose: 1500 mg IV q3wk; Info: part of multi-drug chemo regimen for 1st 4 cycles
[<30 kg]
Dose: 20 mg/kg/dose IV q3wk x4 cycles, then 10 mg/kg/dose IV q2wk; Info: part of multi-drug chemo regimen for 1st 4 cycles

Urothelial carcinoma, locally advanced or metastatic

[indication withdrawn in US]
Info: drug not shown to improve survival in pts w/ locally advanced or metastatic urothelial carcinoma

Renal dosing

CrCl >30: no adjustment; CrCl <30: not defined
HD/PD: not defined

Hepatic dosing

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN and any AST: not defined

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