Durvalumab Dosage
Generic name: durvalumab
Brand name: Imfinzi
Drug class: Anti-PD-1 monoclonal antibodies
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
Restricted Distribution in US
Stage III non-small cell lung CA, unresectable
- [10 mg/kg/dose IV q2wk for up to 12mo]
- Alt: 1500 mg IV q4wk for up to 12mo if wt >30 kg; Info: for non-progressive dz after concurrent platinum-based chemo and XRT
Extensive-stage small cell lung CA, first-line tx
- [>30 kg]
- Dose: 1500 mg IV q3wk; Info: part of multi-drug chemo regimen for 1st 4 cycles
- [<30 kg]
- Dose: 20 mg/kg/dose IV q3wk x4 cycles, then 10 mg/kg/dose IV q2wk; Info: part of multi-drug chemo regimen for 1st 4 cycles
Urothelial carcinoma, locally advanced or metastatic
- [indication withdrawn in US]
- Info: drug not shown to improve survival in pts w/ locally advanced or metastatic urothelial carcinoma
Renal dosing
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
Hepatic dosing
- bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN and any AST: not defined
SRC: NLM .