Droxia Dosage

Generic name: hydroxyurea
Brand names: Droxia, Hydrea, Mylocel, Siklos
Drug class: Antimetabolites

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 200 mg, 300 mg, 400 mg

Sickle cell disease

[15-35 mg/kg/dose PO qd]

Start: 15 mg/kg/dose PO qd; Max: 35 mg/kg/day; Info: titrate by 5 mg/kg/day q12wk

CML, refractory

[individualize dose PO qd]

Start: 15 mg/kg/dose PO qd

Squamous cell head/neck CA, XRT adjunct

[500-1000 mg PO q12h x11 doses each cycle]

Start: approx. 14h prior to initiation of XRT each cycle

Polycythemia vera

[500-1500 mg PO qd]

Info: titrate to control Hct and platelet count

Thrombocythemia, essential

[15 mg/kg/dose PO qd]

Info: titrate to control platelets and maintain WBC count

Renal dosing

[adjust dose amount]

CrCl <60: decr. usual dose by 50%

HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement

Hepatic dosing

[not defined]