Dovato Dosage

Generic name: dolutegravir and lamivudine
Drug class: Antiviral combinations

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 50 mg/300 mg

HIV infection

[tx-naive]
Dose: 1 tab PO qd; Info: for pts w/ HIV-1 RNA <500,000 and no baseline resistance to dolutegravir or lamivudine
[tx-experienced]
Dose: 1 tab PO qd; Info: for pts w/ HIV-1 RNA <50 and no known tx failure or resistance to dolutegravir or lamivudine

Renal dosing

CrCl 30-49: avoid use if lamivudine-related toxicities, otherwise no adjustment; dose adjustment not possible w/ fixed-dose combo; CrCl <30: avoid use; dose adjustment not possible w/ fixed-dose combo
HD/PD: avoid use; dose adjustment not possible w/ fixed-dose combo

Hepatic dosing

[see below]
Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

 

SRC: NLM .