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Doryx

Generic name: Doxycycline Delayed-Release Tablets
Drug classes: Miscellaneous antimalarials, Tetracyclines

Medically reviewed by  A Ras MD.

What is Doryx?

Doryx is a prescription medicine that is used to treat pimples (acne). It is used to treat or prevent bacterial infections. Doryx is also used to prevent malaria. It is used to treat swelling of the tissue around the teeth (periodontitis). It is used with scaling and root planing.

Doryx may be given to you for other reasons. Talk to your doctor.

Description

DORYX Capsules contain specially coated pellets of doxycycline hyclate, a broad-spectrum antibiotic synthetically derived from oxytetracycline, in a delayed-release formulation for oral administration.

The structural formula for doxycycline hyclate is

Image from Drug Label Content

with a molecular formula of C22H24N2O8, HCl, ½ C2H6O, ½ H2O and a molecular weight of 512.9. The chemical designation for doxycycline hyclate is [4S (4aR, 5S, 5aR, 6R, 12aS)]-4-(dimethylamino)-1,4,4a, 5,5a, 6, 11,12a-octahydro-3, 5,10,12,12a-pentahydroxy-6-methyl-1, 11-deoxonapthtacene-2-carboxamide monohydrochloride, compound with ethyl alcohol (2:1), monohydrate.

Doxycycline hyclate is a yellow crystalline powder soluble in water and in solutions of alkali hydroxides and carbonates. Doxycycline has a high degree of lipid solubility and a low affinity for calcium binding. It is highly stable in normal human serum. Doxycycline will not degrade into an epianhydro form.

Inert ingredients in the capsule formulation are: lactose; microcrystalline cellulose; povidone; starch wheat; magnesium stearate; cellulosic polymer coating. The capsule shell and/or band contains FD and C blue No. 1; FD and C yellow No. 6; D and C yellow No. 10; gelatin; silicon dioxide; sodium lauryl sulfate; titanium dioxide.

Before taking Doryx, tell your doctor:

  • If you are allergic to Doryx; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you are taking any of these drugs: Acitretin, isotretinoin, or a penicillin.
  • If you are breast-feeding or plan to breast-feed.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Doryx with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Doryx?

  • Tell all of your health care providers that you take Doryx. This includes your doctors, nurses, pharmacists, and dentists.
  • Have your blood work checked if you are on Doryx for a long time. Talk with your doctor.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Doryx.
  • Do not use longer than you have been told. A second infection may happen.
  • This medicine may make you sunburn more easily. Use care if you will be in the sun. Tell your doctor if you sunburn easily while taking Doryx.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
  • A severe and sometimes deadly reaction has happened. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. If you have questions, talk with the doctor.
  • Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking Doryx.
  • This medicine may cause a change in tooth color to yellow-gray-brown in children younger than 8 years old. If this change of tooth color happens, it will not go away. Talk with the doctor.
  • Most of the time, Doryx is not for use in children younger than 8 years old. However, there may be times when these children may need to take Doryx. Talk with the doctor.
  • Change in tooth color has also happened in adults. This has gone back to normal after Doryx was stopped and teeth cleaning at a dentist’s office. Talk with the doctor.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking Doryx, call your doctor right away.

How is Doryx best taken?

Use Doryx as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Keep taking Doryx as you have been told by your doctor or other health care provider, even if you feel well.
  • Some drugs may need to be taken with food or on an empty stomach. For some drugs it does not matter. Check with your pharmacist about how to take Doryx.
  • It is best to avoid taking Doryx at the same time as milk, dairy, or other products with calcium. This medicine may not work as well. If you have questions, talk with the doctor or pharmacist.
  • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
  • Do not take bismuth (Pepto-Bismol®), calcium, iron, magnesium, zinc, multivitamins with minerals, colestipol, cholestyramine, didanosine, or antacids within 2 hours of Doryx.
  • Take with a full glass of water.
  • Do not lie down for at least 30 minutes after taking Doryx.
  • Swallow whole. Do not chew or crush.
  • The tablet may be broken if the doctor tells you to.
  • You may sprinkle contents of tablet on applesauce. Be careful to break the tablet without crushing the pellets. Do not chew, crush, or damage the contents of the tablet.
  • Swallow the mixture right away. Do not store for use at a later time.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are the side effects of Doryx that I need to call my doctor about immediately?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
  • Chest pain or pressure or a fast heartbeat.
  • Not able to pass urine or change in how much urine is passed.
  • Fever, chills, or sore throat; any unexplained bruising or bleeding; or feeling very tired or weak.
  • Throat irritation.
  • Trouble swallowing.
  • Muscle or joint pain.
  • Fast breathing.
  • Flushing.
  • Very bad dizziness or passing out.
  • Change in skin color.
  • Swollen gland.
  • Vaginal itching or discharge.
  • Diarrhea is common with antibiotics. Rarely, a severe form called C diff–associated diarrhea (CDAD) may happen. Sometimes, this has led to a deadly bowel problem (colitis). CDAD may happen during or a few months after taking antibiotics. Call your doctor right away if you have stomach pain, cramps, or very loose, watery, or bloody stools. Check with your doctor before treating diarrhea.
  • Raised pressure in the brain has happened with Doryx. Most of the time, this will go back to normal after Doryx is stopped. Sometimes, loss of eyesight may happen and may not go away even after Doryx is stopped. Call your doctor right away if you have a headache or eyesight problems like blurred eyesight, seeing double, or loss of eyesight.

What are some other side effects of Doryx?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Not hungry.
  • Upset stomach or throwing up.
  • Diarrhea.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If overdose is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Doryx?

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Do not take Doryx if it is outdated.
  • Do not take Doryx if it has not been stored as you have been told.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Label

PRINCIPAL DISPLAY PANEL – 120 MG TABLET BOTTLE LABEL

  • NDC 51862-559-30
  • Doryx® MPC
    (Doxycycline Hyclate
    Delayed-Release Tablets)
  • 120 mg
  • Do not chew or crush tablets.
  • Rx Only
    30 Tablets
  • mayne pharma
PRINCIPAL DISPLAY PANEL - 120 mg Tablet Bottle Label

SRC: NLM .

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