Diprolene

Generic name: betamethasone topical
Brand names: Diprolene, LuxiqSernivo
Drug class: Topical steroids

Medically reviewed by  A Ras MD.

What is Diprolene?

Diprolene is a prescription medicine that is used to treat psoriasis. It is used to treat skin irritation. Diprolene is also used to treat skin rashes. Diprolene may be given to you for other reasons.

Description

DIPROLENE (augmented betamethasone dipropionate) Ointment, 0.05% contains betamethasone dipropionate USP, a synthetic adrenocorticosteroid, for topical use. Betamethasone, an analog of prednisolone, has a high degree of corticosteroid activity and a slight degree of mineralocorticoid activity. Betamethasone dipropionate is the 17, 21-dipropionate ester of betamethasone.

Chemically, betamethasone dipropionate is 9-fluoro-11β, 17,21-trihydroxy-16β -methylpregna-1,4-diene-3,20-dione 17,21-dipropionate, with the empirical formula C28H37FO7, a molecular weight of 504.6 and the following structural formula:

 
Chemical Structure

It is a white to creamy-white, odorless powder insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in alcohol.

Each gram of DIPROLENE Ointment, 0.05% contains 0.643 mg betamethasone dipropionate USP (equivalent to 0.5 mg betamethasone), in a white ointment base of propylene glycol; propylene glycol stearate; white petrolatum; and white wax.

Mechanism of Action

Corticosteroids play a role in cellular signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action of DIPROLENE Ointment in corticosteroid responsive dermatoses is unknown.

Before taking Diprolene, tell your doctor:

  • If you are allergic to Diprolene; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have thinning of the skin where you are putting Diprolene.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Diprolene with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Diprolene?

  • Tell all of your health care providers that you take Diprolene. This includes your doctors, nurses, pharmacists, and dentists.
  • Do not use longer than you have been told by the doctor.
  • Use care when using on a large part of the skin. Talk with the doctor.
  • Do not use to treat diaper rash or redness. Avoid putting Diprolene in the diaper area.
  • This medicine may raise the chance of cataracts or glaucoma. Talk with the doctor.
  • This medicine may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor.
  • Use with care in children. Talk with the doctor.
  • Different brands of Diprolene may be for use in different ages of children. Talk with the doctor before giving Diprolene to a child.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.
  • If you are breast-feeding, do not put Diprolene right on the nipple or the area right around it.

How is Diprolene best taken?

Use Diprolene as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Use as you have been told, even if your signs get better.
  • Do not take Diprolene by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
  • Do not use coverings (bandages, dressings) unless told to do so by the doctor.
  • Wash your hands before and after use. Do not wash your hands after use if putting this on your hand.
  • Clean affected part before use. Make sure to dry well.
  • Put a thin layer on the affected skin and rub in gently.
  • Do not put on the face, underarms, or the groin area unless told to do so by the doctor.

What do I do if I miss a dose?

  • Put on a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not put on 2 doses at the same time or extra doses.

What are the side effects of Diprolene that I need to call my doctor about immediately?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of a weak adrenal gland like a very bad upset stomach or throwing up, very bad dizziness or passing out, muscle weakness, feeling very tired, mood changes, not hungry, or weight loss.
  • Signs of Cushing’s disease like weight gain in the upper back or belly, moon face, very bad headache, or slow healing.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Skin changes (pimples, stretch marks, slow healing, hair growth).
  • Skin irritation.
  • Thinning of the skin.
  • Change in eyesight.

What are some other side effects of Diprolene?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Burning or stinging.
  • Dry skin.
  • Itching.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If overdose is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Diprolene?

  • Store at room temperature. Do not freeze.
  • Protect from light.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

 

Label

PRINCIPAL DISPLAY PANEL – 15 G TUBE BOX

  • NDC 78206-124-01
  • 15 g
  • Diprolene®
  • (augmented
    betamethasone
    dipropionate)
  • Ointment, 0.05%*
  • *Strength expressed
    as betamethasone
  • For topical
    use only.
  • Not for oral,
    ophthalmic, or
    intravaginal use.
  • Rx only
PRINCIPAL DISPLAY PANEL - 15 g Tube Box

 

SRC: NLM .