DIFFERIN CREAM SIDE EFFECTS
- Generic Name: adapalene cream
- Brand Name: Differin Cream
- Drug Class: Acne Agents, Topical
SIDE EFFECTS
In controlled clinical trials, local cutaneous irritation was monitored in 285 acne patients who used DIFFERIN Cream once daily for 12 weeks. The frequency and severity of erythema, scaling, dryness, pruritus and burning were assessed during these studies. The incidence of local cutaneous irritation with DIFFERIN® Cream from the controlled clinical studies is provided in the following table:
Incidence of Local Cutaneous Irritation with DIFFERIN® Cream from Controlled Clinical Studies (N=285)
| Incidence of Local Cutaneous Irritation with DIFFERIN® Cream from Controlled Clinical Studies (N=285) | ||||
| None | Mild | Moderate | Severe | |
| Erythema | 52% (148) | 38% (108) | 10% (28) | < 1% (1) |
| Scaling | 58% (166) | 35% (100) | 6% (18) | <1% (1) |
| Dryness | 48% (136) | 42% (121) | 9% (26) | <1% (2) |
| Pruritus (persistent) | 74% (211) | 21% (61) | 4% (12) | <1% (1) |
| Burning/Stinging (persistent) | 71% (202) | 24% (69) | 4% (12) | <1% (2) |
Other reported local cutaneous adverse events in patients who used DIFFERIN Cream once daily included: sunburn (2%), skin discomfortburning and stinging (1%) and skin irritation (1%). Events occurring in less than 1% of patients treated with DIFFERIN Cream included: acne flare, dermatitis and contact dermatitis, eyelid edema, conjunctivitis, erythema, pruritus, skin discoloration, rash, and eczema.
SRC: NLM .