Defitelio Dosage

Generic name: defibrotide
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Hepatic veno-occlusive dz

[6.25 mg/kg/dose IV q6h for at least 21 days]

Max: 60 days; Info: for pts w/ renal or pulmonary dysfunction after hematopoietic stem cell transplant; dose based on wt prior to transplant; D/C at least 2h before invasive procedure

Renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

Hepatic dosing

[not defined]

Recommended Peds Dosing

Dosage forms:  INJ

Hepatic veno-occlusive dz

[6.25 mg/kg/dose IV q6h for at least 21 days]

Max: 60 days; Info: for pts w/ renal or pulmonary dysfunction after hematopoietic stem cell transplant; dose based on wt prior to transplant; D/C at least 2h before an invasive procedure

Renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .