Daurismo Dosage

Generic name: glasdegib
Drug class: Hedgehog pathway inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 25 mg, 100 mg

AML, newly diagnosed

[100 mg PO qd on days 1-28 of 28-day cycle]

Info: for pts 75 yo and older, or who are ineligible for intensive induction chemo d/t comorbidities; use w/ low-dose cytarabine; give for at least 6 cycles; do not cut/crush/chew tab

Renal dosing

eGFR >15: no adjustment; eGFR <15: not defined; Info: caution advised if eGFR 15-29

HD/PD: not defined

Hepatic dosing

bilirubin 1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN and any AST: not defined

SRC: NLM .