Dasatinib Dosage

Generic name: dasatinib
Brand name: Sprycel
Dosage form: oral tablet (100 mg; 140 mg; 20 mg; 50 mg; 70 mg; 80 mg)
Drug class: BCR-ABL tyrosine kinase inhibitors

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 20 mg, 50 mg, 70 mg, 80 mg, 100 mg, 140 mg

CML, Ph-positive

[chronic phase, newly diagnosed]
Dose: 100 mg PO qd; Info: may incr. dose to 140 mg PO qd; do not cut/crush/chew tab
[chronic phase, resistant or intolerant dz]
Dose: 100 mg PO qd; Info: may incr. dose to 140 mg PO qd; do not cut/crush/chew tab
[accelerated phase or blast phase, resistant or intolerant dz]
Dose: 140 mg PO qd; Info: may incr. dose to 180 mg PO qd; do not cut/crush/chew tab

ALL Ph-positive, relapsed or refractory

[140 mg PO qd]
Info: may incr. dose to 180 mg PO qd; do not cut/crush/chew tab

Renal dosing

[see below]
renal impairment: no adjustment
HD/PD: not defined

Hepatic dosing

[not defined]

 Recommended Peds Dosing

Dosage forms:  TAB: 20 mg, 50 mg, 70 mg, 80 mg, 100 mg, 140 mg

Special Note

[uses, dosing may vary]
Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; recalculate dose q3mo based on changes in wt

CML Ph-positive, chronic phase

[1 yo and older, 10-19 kg]
Dose: 40 mg PO qd; Info: may incr. dose to 50 mg PO qd; do not cut/crush/chew tab
[1 yo and older, 20-29 kg]
Dose: 60 mg PO qd; Info: may incr. dose to 70 mg PO qd; do not cut/crush/chew tab
[1 yo and older, 30-44 kg]
Dose: 70 mg PO qd; Info: may incr. dose to 90 mg PO qd; do not cut/crush/chew tab
[1 yo and older, >45 kg]
Dose: 100 mg PO qd; Info: may incr. dose to 120 mg PO qd; do not cut/crush/chew tab

 ALL Ph-positive, newly diagnosed

[1 yo and older, 10-19 kg]
Dose: 40 mg PO qd x2y; Start: on or before day 15 of induction chemo; Info: do not cut/crush/chew tab; part of multi-drug chemo regimen
[1 yo and older, 20-29 kg]
Dose: 60 mg PO qd x2y; Start: on or before day 15 of induction chemo; Info: do not cut/crush/chew tab; part of multi-drug chemo regimen
[1 yo and older, 30-44 kg]
Dose: 70 mg PO qd x2y; Start: on or before day 15 of induction chemo; Info: do not cut/crush/chew tab; part of multi-drug chemo regimen
[1 yo and older, >45 kg]
Dose: 100 mg PO qd x2y; Start: on or before day 15 of induction chemo; Info: do not cut/crush/chew tab; part of multi-drug chemo regimen

Renal dosing

[not defined]
renal impairment: consider adult renal dosing for guidance
HD/PD: not defined

Hepatic dosing

[not defined]

 

SRC: NLM .