Daraprim Dosage

Generic name: pyrimethamine
Drug class: Miscellaneous antimalarials

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 25 mg

Toxoplasmosis

[*prophylaxis, primary]

Dose: 50-75 mg PO qwk; Info: not 1st-line agent; give w/ dapsone, leucovorin

[treatment, <60 kg]

Dose: 200 mg PO x1, then 50 mg PO qd for at least 6wk; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

[treatment, >60 kg]

Dose: 200 mg PO x1, then 75 mg PO qd for at least 6wk; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

[*maintenance tx, <60 kg]

Dose: 25 mg PO qd; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

[*maintenance tx, >60 kg]

Dose: 50 mg PO qd; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

PCP prophylaxis

[50-75 mg PO qwk]

Info: not 1st-line agent; give w/ dapsone, leucovorin

Cystoisosporiasis

[acute infection treatment]

Dose: 50-75 mg PO qd; Info: not 1st-line agent; give w/ leucovorin

[chronic maintenance therapy]

Dose: 25 mg PO qd; Info: not 1st-line agent; give w/ leucovorin

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

[not defined]

hepatic impairment: caution advised

 Recommended Peds Dosing

Dosage forms:  TAB: 25 mg

Toxoplasmosis

[*primary prophylaxis, 1 mo and older]

Dose: 1 mg/kg/dose PO qd; Max: 25 mg/day; Info: give with w/ dapsone, leucovorin

[treatment, congenital infection]

Dose: 2 mg/kg/dose PO qd x2 days, then 1 mg/kg/dose PO qd x2-6mo, then 1 mg/kg/dose PO 3x/wk to complete total of 12mo; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

[treatment, acquired infection]

Dose: 1 mg/kg/dose PO qd for at least 6wk; Start: 2 mg/kg/dose PO qd x3 days, max 50 mg/day; Max: 25 mg/day; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

[suppressive therapy]

Dose: 1 mg/kg/dose PO qd; Max: 25 mg/day; Alt: 15 mg/m^2/dose PO qd; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

Cystoisosporiasis

[1 mg/kg/dose PO qd]

Max: 25 mg/day; Info: not 1st-line agent; give w/ leucovorin

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

Hepatic dosing

[not defined]

hepatic impairment: caution advised

SRC: NLM .