Dapsone Dosage

Generic name: dapsone
Dosage form: oral tablet (100 mg; 25 mg)
Drug class: Leprostatics

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 25 mg, 100 mg

Leprosy (Hansen dz), paucibacillary

[100 mg PO qd x6mo]

Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 6mo in non-resistant refractory cases

Leprosy (Hansen dz), multibacillary

[100 mg PO qd x12mo]

Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 12mo in non-resistant refractory cases

Dermatitis herpetiformis

[50 mg PO qd]

PCP prophylaxis

[monotherapy]

Dose: 100 mg/day PO divided qd-bid; Info: not 1st-line agent

[combo tx w/ pyrimethamine, leucovorin]

Dose: 50 mg PO qd; Alt: 200 mg PO qwk; Info: not 1st-line agent

PCP tx, mild-mod.

[100 mg PO qd x21 days]

Info: not 1st-line agent; give w/ trimethoprim

Toxoplasmosis prophylaxis, primary

[50 mg PO qd]

Alt: 200 mg PO qwk; Info: not 1st-line agent; give w/ pyrimethamine, leucovorin

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD: no adjustment, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: no adjustment; no supplement

Hepatic dosing

[not defined]

hepatic impairment: caution advised

SRC: NLM .