Dactinomycin Dosage
Generic name: dactinomycin
Brand name: Cosmegen
Drug class: Antibiotics / antineoplastics
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
Wilms tumor
- [45 mcg/kg/dose IV q3-6wk for up to 26wk]
- Info: part of multi-drug chemo regimen
Rhabdomyosarcoma
- [15 mcg/kg/dose IV qd x5 days q3-9wk for up to 112wk]
- Info: part of multi-drug chemo regimen
Ewing sarcoma
- [1250 mcg/m^2/dose IV x1 on day 1 of 21-day cycle x17 cycles]
- Info: part of multi-drug chemo regimen
Gestational trophoblastic neoplasia
- [low-risk and non-metastatic dz, monotherapy]
- Dose: 12 mcg/kg/dose IV qd x5 days
- [high-risk metastatic dz, combo tx]
- Dose: 500 mcg IV x1 on days 1-2 of 14-day cycle for up to 4 cycles
Solid malignancy, locally recurrent or locoregional
- [lower extremity or pelvis]
- Dose: 50 mcg/kg/dose via regional perfusion x1; Info: for adjunctive or palliative tx; use w/ melphalan
- [upper extremity]
- Dose: 35 mcg/kg/dose via regional perfusion x1; Info: for adjunctive or palliative tx; use w/ melphalan
Nonseminomatous testicular CA, metastatic
- [1000 mcg/m^2/dose IV x1 on day 1 of 21-day cycle x4 cycles]
- Info: part of multi-drug chemo regimen
Osteosarcoma
- [600 mcg/m^2/dose IV x1 on days 1-3 of tx wk 15, 31, 34, 39, and 42]
- Info: part of multi-drug chemo regimen
Renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
Hepatic dosing
- [not defined]
Recommended Peds Dosing
- Dosage forms: INJ
Wilms tumor
- [45 mcg/kg/dose IV q3-6wk for up to 26wk]
- Info: part of multi-drug chemo regimen
Rhabdomyosarcoma
- [15 mcg/kg/dose IV qd x5 days q3-9wk for up to 112wk]
- Info: part of multi-drug chemo regimen
Ewing sarcoma
- [1250 mcg/m^2/dose IV x1 on day 1 of 21-day cycle x17 cycles]
- Info: part of multi-drug chemo regimen
Gestational trophoblastic neoplasia
- [low-risk and non-metastatic dz, monotherapy, postmenarchal pts]
- Dose: 12 mcg/kg/dose IV qd x5 days
- [high-risk metastatic dz, combo tx, postmenarchal pts]
- Dose: 500 mcg IV x1 on days 1-2 of 14-day cycle for up to 4 cycles
Nonseminomatous testicular CA, metastatic
- [1000 mcg/m^2/dose IV x1 on day 1 of 21-day cycle x4 cycles]
- Info: part of multi-drug chemo regimen
Osteosarcoma
- [600 mcg/m^2/dose IV x1 on days 1-3 of tx wk 15, 31, 34, 39, and 42]
- Info: part of multi-drug chemo regimen
Renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
Hepatic dosing
- [not defined]
SRC: NLM .