Cyramza Dosage

Generic name: ramucirumab
Drug class: VEGF/VEGFR inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Gastric CA, advanced or metastatic

[8 mg/kg/dose IV q2wk]

Info: for pts w/ gastric or gastroesophageal junction adenocarcinoma w/ dz progression on or after fluoropyrimidine- or platinum-containing chemo; use as monotherapy or w/ paclitaxel

Non-small cell lung CA, metastatic

[first-line tx]

Dose: 10 mg/kg/dose IV q2wk; Info: for pts w/ EGFR exon 19 deletions or exon 21 (L858R) substitution mutations; use w/ erlotinib

[progressive dz]

Dose: 10 mg/kg/dose IV x1 on day 1 of 21-day cycle; Info: for pts w/ dz progression on or after platinum-based chemo; use w/ docetaxel

Colorectal CA, progressive metastatic

[8 mg/kg/dose IV q2wk]

Info: for pts w/ disease progression on or after bevacizumab, oxaliplatin, and a fluoropyrimidine; use w/ FOLFIRI as part of multi-drug chemo regimen

Hepatocellular CA

[8 mg/kg/dose IV q2wk]

Info: for pts w/ dz progression on or after sorafenib and w/ alpha fetoprotein 400 ng/mL or greater

Renal dosing

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

Hepatic dosing

[see below]

bilirubin 1.1-3x ULN or AST >ULN: no adjustment; bilirubin >3x ULN and any AST: not defined

SRC: NLM .