Cyklokapron Dosage

Generic name: tranexamic acid (Cyklokapron)
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Dental bleeding prophylaxis, hemophilia pts

[10 mg/kg/dose IV tid-qid x2-8 days]

Start: 10 mg/kg/dose IV x1 immed. preop; Info: use w/ factor replacement tx

Postpartum hemorrhage

[1000 mg IV x1]

Start: w/in 3h of delivery; Info: may repeat x1; refer to institution protocol

*Hemorrhage, trauma-assoc.

[1000 mg IV x1, then 1000 mg IV over 8h]

Start: w/in 3h of injury

Bleeding prophylaxis, hip replacement

[IV route]

Dose: 1000 mg IV x1 prior to incision, then may give 1000 mg IV x1 periop and/or postop; Alt: 10-15 mg/kg/dose IV x1, then 1 mg/kg/h IV infusion x10h; Info: refer to institution protocol

[topical route]

Dose: 2000 mg irrigation x1; Info: for intraop use; refer to institution protocol

Bleeding prophylaxis, knee replacement

[IV route]

Dose: 1000 mg IV x1 prior to incision, then may give 1000 mg IV x1 periop and/or postop; Alt: 10-15 mg/kg/dose IV x1, then 1 mg/kg/h IV infusion x6h; Info: refer to institution protocol

[topical route]

Dose: 2000 mg irrigation x1; Info: for intraop use; refer to institution protocol

Bleeding prophylaxis, cardiac surgery

[50 mg/kg/dose IV x1 >30min after anesthesia induction]

Alt: 30 mg/kg/dose IV x1 prior to incision, then 16 mg/kg/h IV until sternal closure; Info: refer to institution protocol; consider adding prime dose to cardiopulmonary bypass circuit

Renal dosing

[dental bleeding prophylaxis]

Cr 1.36-2.83: 10 mg/kg/dose bid; Cr 2.83-5.66: 10 mg/kg/dose qd; Cr >5.66: 10 mg/kg/dose q48h or 5 mg/kg/dose qd

HD/PD: not defined

[off-label uses]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

 Recommended Peds Dosing

Dosage forms:  INJ

Dental bleeding prophylaxis, hemophilia pts

[10 mg/kg/dose IV tid-qid x2-8 days]

Start: 10 mg/kg/dose IV x1 immed. preop; Info: use w/ factor replacement tx

Bleeding prophylaxis, cardiac surgery

[2 mo and older]

Dose: 1-10 mg/kg/h IV; Start: 10-100 mg/kg/dose IV x1 after anesthesia induction; Max: 2000 mg/dose; Info: refer to institution protocol; consider adding prime dose to cardiopulmonary bypass circuit

Renal dosing

[dental bleeding prophylaxis]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

[off-label use]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .