Cyklokapron

Generic name: tranexamic acid (Cyklokapron)
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by  A Ras MD.

What is Cyklokapron?

Cyklokapron is a prescription medicine that is used to treat or prevent bleeding in patients with hemophilia after having a tooth removed. Cyklokapron may be given to you for other reasons.

Description

Tranexamic acid is trans-4-(aminomethyl)cyclohexanecarboxylic acid, an antifibrinolytic agent. Tranexamic acid is a white crystalline powder. The structural formula is

• Empirical Formula: C8H15NO2                         
• Molecular Weight: 157.2

Each mL of the sterile solution for intravenous injection contains 100 mg tranexamic acid and Water for Injection to 1 mL. The aqueous solution for injection has a pH of 6.5 to 8.0.

Mechanism of Action

Tranexamic acid is a synthetic lysine amino acid derivative, which diminishes the dissolution of hemostatic fibrin by plasmin. In the presence of tranexamic acid, the lysine receptor binding sites of plasmin for fibrin are occupied, preventing binding to fibrin monomers, thus preserving and stabilizing fibrin’s matrix structure.

The antifibrinolytic effects of tranexamic acid are mediated by reversible interactions at multiple binding sites within plasminogen. Native human plasminogen contains 4 to 5 lysine binding sites with low affinity for tranexamic acid (Kd = 750 μmol/L) and 1 with high affinity (Kd = 1.1 μmol/L). The high affinity lysine site of plasminogen is involved in its binding to fibrin. Saturation of the high affinity binding site with tranexamic acid displaces plasminogen from the surface of fibrin. Although plasmin may be formed by conformational changes in plasminogen, binding to and dissolution of the fibrin matrix is inhibited.

Before taking Cyklokapron, tell your doctor:

• If you are allergic to Cyklokapron; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have a blood clot, have ever had a blood clot, or have been told you are at risk of getting a blood clot.
• If you have any of these health problems: Bleeding in the brain or trouble seeing some colors.
• If you are taking any of these drugs: Factor IX complex or anti-inhibitor coagulant complex.
• If you are using a hormone-based birth control.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Cyklokapron with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Cyklokapron?

• Tell all of your health care providers that you take Cyklokapron. This includes your doctors, nurses, pharmacists, and dentists.
• Avoid driving and doing other tasks or actions that call for you to be alert until you see how Cyklokapron affects you.
• Blood clots have happened with Cyklokapron. Tell your doctor if you have ever had a blood clot. Talk with your doctor.
• Have an eye exam as you have been told by your doctor.
• Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is Cyklokapron best taken?

Use Cyklokapron as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• It is given into a vein for a period of time.

What do I do if I miss a dose?

• Call your doctor to find out what to do.

What are the side effects of Cyklokapron that I need to call my doctor about immediately?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Flushing.
• Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
• Very bad headache.
• Change in eyesight, eye pain, or very bad eye irritation.
• Feeling very tired or weak.
• Seizures.
• Very bad dizziness or passing out.
• Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.

What are some other side effects of Cyklokapron?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Upset stomach or throwing up.
• Diarrhea.
• Dizziness.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If overdose is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Cyklokapron?

• If you need to store Cyklokapron at home, talk with your doctor, nurse, or pharmacist about how to store it.

Label

PRINCIPAL DISPLAY PANEL – 10 ML AMPULE CARTON – NDC 0013-1114-01

• NDC 0013-1114-01
• Contains 1 Ampule 10 mL
  Cyklokapron®
  tranexamic acid injection
• 1000 mg/10 mL
  (100 mg/mL)
• Solution for intravenous injection
• Single-Dose ONLY
  Discard any remaining portion
  after single use
• Rx only
• Pfizer Injectables

SRC: NLM .