Cycloserine Dosage

Generic name: cycloserine
Brand name: Seromycin
Dosage form: oral capsule (250 mg)
Drug class: Streptomyces derivatives

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 250 mg

tuberculosis, active

[10-15 mg/kg/day PO divided qd-bid]

Start: 250 mg PO qd; Max: 1000 mg/day; Info: part of multi-drug regimen; not 1st-line agent

UTI

[250 mg PO q12h x14 days]

Renal dosing

[tuberculosis, active]

severe impairment: contraindicated per pkg insert; Alt: 500 mg 3x/wk or 250 mg daily if CrCl <30

HD: 500 mg 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; Alt: 250 mg daily, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined

[UTI]

CrCl 10-50: 250 mg q24h; CrCl <10: contraindicated

HD/PD: not defined

Hepatic dosing

[not defined]

 Recommended Peds Dosing

Dosage forms:  CAP: 250 mg

Tuberculosis, active

[2-14 yo]

Dose: 15-20 mg/kg/day PO divided qd-bid; Max: 1000 mg/day; Info: part of multi-drug regimen; not 1st-line agent

[15 yo and older]

Dose: 10-15 mg/kg/day PO divided qd-bid; Start: 250 mg PO qd; Max: 1000 mg/day; Info: part of multi-drug regimen; not 1st-line agent

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD: not defined, consider adult renal dosing for guidance; PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .