Crysvita Dosage

Generic name: burosumab
Drug class: Miscellaneous metabolic agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ: 10 mg per mL, 20 mg per mL, 30 mg per mL

X-linked hypophosphatemia

[1 mg/kg/dose SC q4wk]

Max: 90 mg/dose; 1.5 mL/injection site; Info: adjust dose based PO4 levels; adjust dose no more frequently than q4wk; see pkg insert for dose decr. recommendations

FGF23-related hypophosphatemia, tumor-induced osteomalacia-assoc.

[individualize dose SC q2-4wk]

Start: 0.5 mg/kg/dose SC q4wk; Max: 2 mg/kg/dose up to 180 mg/dose q2wk; Info: for phosphaturic mesenchymal tumors that cannot be curatively resected or localized; adjust dose based PO4 levels; adjust dose no more frequently than q4wk; see pkg insert for dose adjustment recommendations

Renal dosing

[see below]

CrCl <30: contraindicated

HD/PD: not defined

Hepatic dosing

[not defined]

Recommended Peds Dosing

Dosage forms:  INJ: 10 mg per mL, 20 mg per mL, 30 mg per mL

X-linked hypophosphatemia

[6 mo and older, <10 kg]

Dose: 0.5-2 mg/kg/dose SC q2wk; Start: 1 mg/kg/dose SC q2wk, then after 4wk, may incr. dose to 1.5 mg/kg/dose SC q2wk; Max: 2 mg/kg/dose q2wk; 1.5 mL/injection site; Info: adjust dose based PO4 levels; adjust dose no more frequently than q4wk; see pkg insert for dose decr. recommendations

[6 mo and older, >10 kg]

Dose: 0.8-2 mg/kg/dose SC q2wk; Start: 0.8 mg/kg/dose SC q2wk, then after 4wk, may incr. dose to 2 mg/kg/dose SC q2wk; Max: 90 mg/dose; 1.5 mL/injection site; Info: start minimum of 10 mg/dose; adjust dose based PO4 levels; adjust dose no more frequently than q4wk; see pkg insert for dose decr. recommendations

FGF23-related hypophosphatemia, tumor-induced osteomalacia-assoc.

[2 yo and older]

Dose: individualize dose SC q2wk; Start: 0.4 mg/kg/dose SC q2wk; Max: 2 mg/kg/dose up to 180 mg/dose q2wk; Info: for phosphaturic mesenchymal tumors that cannot be curatively resected or localized; adjust dose based PO4 levels; adjust dose no more frequently than q4wk; see pkg insert for dose adjustment recommendations

Renal dosing

[see below]

eGFR <30: contraindicated

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .