Creon Dosage

Generic name: pancrelipase
Drug class: Digestive enzymes

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  DR CAP (lipase/protease/amylase): 6K units/19K units/30K units, 12K units/38K units/60K units, 24K units/76K units/120K units, 36K units/114K units/180K units

Exocrine pancreatic insufficiency

[500-2500 lipase units/kg/dose PO w/ each meal/snack]

Start: 500 lipase units/kg/dose PO w/ each meal/snack; Alt: 500-4000 lipase units/g fat ingested/day PO divided w/ meals/snacks; Info: snack dose usually half of meal dose; may open caps and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; doses >2500 lipase units/kg/meal, 4000 lipase units/g fat ingested/day, or 10,000 lipase units/kg/day require objective evidence of improved efficacy

Renal dosing

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

Hepatic dosing

[not defined]

 Recommended Peds Dosing

Dosage forms:  DR CAP (lipase/protease/amylase): 3K units/9.5K units/15K units, 6K units/19K units/30K units, 12K units/38K units/60K units, 24K units/76K units/120K units, 36K units/114K units/180K units

Exocrine pancreatic insufficiency

[<1 yo]

Dose: 3000 lipase units PO per breastfeeding or 4 oz formula; Info: may open caps and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; give before breastfeeding or formula

[1-3 yo]

Dose: 1000-2500 lipase units/kg/dose PO w/ each meal/snack; Start: 1000 lipase units/kg/dose PO w/ each meal/snack; Max: 6000 lipase units/kg/meal; Alt: 500-4000 lipase units/g fat ingested/day PO divided w/ meals/snacks; Info: snack dose usually half of meal dose; may open caps and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; doses >2500 lipase units/kg/meal, 4000 lipase units/g fat ingested/day, or 10,000 lipase units/kg/day require objective evidence of improved efficacy

[4-11 yo]

Dose: 500-2500 lipase units/kg/dose PO w/ each meal/snack; Start: 500 lipase units/kg/dose PO w/ each meal/snack; Max: 6000 lipase units/kg/meal; Alt: 500-4000 lipase units/g fat ingested/day PO divided w/ meals/snacks; Info: snack dose usually half of meal dose; may open caps and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; doses >2500 lipase units/kg/meal, 4000 lipase units/g fat ingested/day, or 10,000 lipase units/kg/day require objective evidence of improved efficacy

[12 yo and older]

Dose: 500-2500 lipase units/kg/dose PO w/ each meal/snack; Start: 500 lipase units/kg/dose PO w/ each meal/snack; Alt: 500-4000 lipase units/g fat ingested/day PO divided w/ meals/snacks; Info: snack dose usually half of meal dose; may open caps and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; doses >2500 lipase units/kg/meal, 4000 lipase units/g fat ingested/day, or 10,000 lipase units/kg/day require objective evidence of improved efficacy

Renal dosing

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

Hepatic dosing

[not defined]

SRC: NLM .