Jump To

Corlanor Dosage

Generic name: ivabradine
Drug class: Miscellaneous cardiovascular agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 5 mg, 7.5 mg; SOL: 1 mg per mL

Heart failure

[2.5-7.5 mg PO bid]
Start: 5 mg PO bid x2wk, then may adjust dose by 5 mg/day to maintain resting HR 50-60; Max: 15 mg/day; Info: for pts w/ LVEF 35% or lower and resting HR at least 70; start 2.5 mg PO bid in pts w/ conduction defect hx or hemodynamic compromise risk; give w/ meals

Renal dosing

[see below]
CrCl >15: no adjustment; CrCl <15: not defined
HD/PD: not defined

Hepatic dosing

[see below]
Child-Pugh Class C: contraindicated

Recommended Peds Dosing

Dosage forms:  TAB: 5 mg, 7.5 mg; SOL: 1 mg per mL

Heart failure, dilated cardiomyopathy

[6-11 mo, <40 kg]
Dose: 0.05-0.2 mg/kg/dose PO bid; Start: 0.05 mg/kg/dose PO bid, then may adjust dose by 0.1 mg/kg/day q2wk to target HR decr. at least 20% as tolerated; Max: 0.2 mg/kg/dose; 15 mg/day; Info: for pts in sinus rhythm w/ elev. HR; give w/ meals
[1 yo and older, <40 kg]
Dose: 0.05-0.3 mg/kg/dose PO bid; Start: 0.05 mg/kg/dose PO bid, then may adjust dose by 0.1 mg/kg/day q2wk to target HR decr. at least 20% as tolerated; Max: 0.3 mg/kg/dose; 15 mg/day; Info: for pts in sinus rhythm w/ elev. HR; give w/ meals
[6 mo and older, >40 kg]
Dose: 2.5-7.5 mg PO bid; Start: 2.5 mg PO bid, then may adjust dose by 5 mg/day q2wk to target HR decr. at least 20% as tolerated; Max: 15 mg/day; Info: for pts in sinus rhythm w/ elev. HR; give w/ meals

Renal dosing

[see below]
CrCl >15: no adjustment; CrCl <15: not defined
HD/PD: not defined

Hepatic dosing

[see below]
Child-Pugh Class C: contraindicated

SRC: NLM .

Read Next Article

PHP Code Snippets Powered By : XYZScripts.com