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Complera Dosage

Generic name: emtricitabine, rilpivirine, and tenofovir
Brand names: CompleraOdefsey
Drug class: Antiviral combinations

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 200 mg/25 mg/300 mg

HIV infection

[tx-naive]
Dose: 1 tab PO qd; Info: for pts w/ HIV-1 RNA <100,000 and CD4 >200; give w/ food
[tx-experienced]
Dose: 1 tab PO qd; Info: for pts w/ HIV-1 RNA <50; give w/ food
[pregnant pts]
Dose: 1 tab PO qd; Info: for pts w/ HIV-1 RNA <50 on stable rilpivirine-containing regimen prior to pregnancy; give w/ food

HIV post-exposure prophylaxis, nonoccupational

[1 tab PO qd]
Info: refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give w/ food

Renal dosing

CrCl <50: avoid use; dose adjustment not possible w/ fixed-dose combo
HD/PD: avoid use; dose adjustment not possible w/ fixed-dose combo

Hepatic dosing

[see below]
Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

 Recommended Peds Dosing

Dosage forms:  TAB: 200 mg/25 mg/300 mg

HIV infection

[>35 kg, tx-naive]
Dose: 1 tab PO qd; Info: for pts w/ HIV-1 RNA <100,000; give w/ food
[>35 kg, tx-experienced]
Dose: 1 tab PO qd; Info: for pts w/ HIV-1 RNA <50; give w/ food
[pregnant pts]
Dose: 1 tab PO qd; Info: for pts w/ HIV-1 RNA <50 on stable rilpivirine-containing regimen prior to pregnancy; give w/ food

Renal dosing

CrCl <50: avoid use; dose adjustment not possible w/ fixed-dose combo
HD/PD: avoid use; dose adjustment not possible w/ fixed-dose combo

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

 

SRC: NLM .

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