Coartem Dosage

Generic name: artemether and lumefantrine
Drug class: Antimalarial combinations

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 20 mg/120 mg

Malaria, uncomplicated

[4 tabs PO bid x3 days]

Info: use Peds Dosing for adults <35 kg; give 2nd dose 8h after 1st dose on day 1; repeat dose if vomiting occurs w/in 30min; give w/ food or milk; tabs may be crushed and mixed w/ 5-10 mL water; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

Renal dosing

mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised

HD/PD: not defined

Hepatic dosing

mild-moderate impairment: no adjustment; severe impairment: caution advised

Recommended Peds Dosing

Dosage forms:  TAB: 20 mg/120 mg

Malaria, uncomplicated

[2 mo and older, 5-14 kg]

Dose: 1 tab PO bid x3 days; Info: give 2nd dose 8h after 1st dose on day 1; repeat dose if vomiting occurs w/in 30min; give w/ food or milk; tabs may be crushed and mixed w/ 5-10 mL water; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

[2 mo and older, 15-24 kg]

Dose: 2 tabs PO bid x3 days; Info: give 2nd dose 8h after 1st dose on day 1; repeat dose if vomiting occurs w/in 30min; give w/ food or milk; tabs may be crushed and mixed w/ 5-10 mL water; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

[2 mo and older, 25-34 kg]

Dose: 3 tabs PO bid x3 days; Info: give 2nd dose 8h after 1st dose on day 1; repeat dose if vomiting occurs w/in 30min; give w/ food or milk; tabs may be crushed and mixed w/ 5-10 mL water; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

[2 mo and older, >35 kg]

Dose: 4 tabs PO bid x3 days; Info: give 2nd dose 8h after 1st dose on day 1; repeat dose if vomiting occurs w/in 30min; give w/ food or milk; tabs may be crushed and mixed w/ 5-10 mL water; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

Renal dosing

mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised

HD/PD: not defined

Hepatic dosing

mild-moderate impairment: no adjustment; severe impairment: caution advised

SRC: NLM .