Cerdelga Dosage
Generic name: eliglustat
Drug class: Miscellaneous metabolic agents
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: CAP: 84 mg
Gaucher disease
- [extensive CYP2D6 metabolizer]
- Dose: 84 mg PO bid; Info: if switching from another enzyme replacement tx, start w/ previous enzyme replacement dose 24h after last admin; do not open/dissolve cap
- [intermediate CYP2D6 metabolizer]
- Dose: 84 mg PO bid; Info: if switching from another enzyme replacement tx, start w/ previous enzyme replacement dose 24h after last admin; do not open/dissolve cap
- [poor CYP2D6 metabolizer]
- Dose: 84 mg PO qd; Info: if switching from another enzyme replacement tx, start w/ previous enzyme replacement dose 24h after last admin; do not open/dissolve cap
Renal dosing
- [extensive CYP2D6 metabolizer]
- CrCl <15: avoid use
- HD/PD: avoid use
- [intermediate or poor CYP2D6 metabolizer]
- renal impairment: avoid use
- HD/PD: avoid use
Hepatic dosing
- [extensive CYP2D6 metabolizer]
- Child-Pugh Class A: recommendations may vary based on concomitant drugs, see drug interactions; Child-Pugh Class B or C: contraindicated
- [intermediate CYP2D6 metabolizer]
- hepatic impairment: contraindicated
- [poor CYP2D6 metabolizer]
- hepatic impairment: contraindicated
SRC: NLM .