Cellcept Dosage

Generic name: mycophenolate mofetil (oral/injection)
Drug class: Selective immunosuppressants

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 250 mg; TAB: 500 mg; SUSP: 200 mg per mL; INJ: various

Special Note

[formulation clarification]

Info: mycophenolate mofetil oral products are not interchangeable w/ mycophenolic acid DR products; do not substitute on a mg to mg basis

Kidney transplant rejection prophylaxis

[1 g PO/IV bid]

Start: ASAP w/ in 24h post transplant; Info: for pts unable to take PO, give IV for up to 14 days and switch to PO ASAP; give on empty stomach; stable pts may take w/ food; do not open cap; do not cut/crush/chew tab

Heart transplant rejection prophylaxis

[1.5 g PO/IV bid]

Start: ASAP w/ in 24h post transplant; Info: for pts unable to take PO, give IV for up to 14 days and switch to PO ASAP; give on empty stomach; stable pts may take w/ food; do not open cap; do not cut/crush/chew tab

Liver transplant rejection prophylaxis

[PO route]

Dose: 1.5 g PO bid; Start: ASAP w/ in 24h post transplant; Info: give on empty stomach; stable pts may take w/ food; do not open cap; do not cut/crush/chew tab

[IV route]

Dose: 1 g IV bid; Start: ASAP w/ in 24h post transplant; Info: for pts unable to take PO; give for up to 14 days and switch to PO ASAP

*Lupus nephritis

[1 g PO bid]

Info: use w/ prednisone; consider decrease. dose 50% after 6mo of tx; do not open cap; do not cut/crush/chew tab

Renal dosing

[kidney transplant pts]

CrCl <25: max 1 g bid

HD: 250-500 mg bid; no supplement after dialysis; PD: max 1 g bid; no supplement

[all other indications]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[kidney transplant pts]

severe hepatic parenchymal disease: no adjustment; other hepatic impairment: not defined

[heart or liver transplant pts]

hepatic impairment: not defined

Recommended Peds Dosing

Dosage forms:  CAP: 250 mg; TAB: 500 mg; SUSP: 200 mg per mL

Special Note

[formulation clarification]

Info: mycophenolate mofetil oral products are not interchangeable w/ mycophenolic acid DR products; do not substitute on a mg to mg basis

Kidney transplant rejection prophylaxis

[3 mo and older]

Dose: 600 mg/m^2/dose PO bid; Start: ASAP w/in 24h post transplant; Max: 2 g/day; Alt: 750 mg PO bid for BSA 1.25-1.5 m^2; 1 g PO bid for BSA >1.5 m^2; Info: give on empty stomach; stable pts may take w/ food; do not open cap; do not cut/crush/chew tab

Heart transplant rejection prophylaxis

[3 mo and older]

Dose: 900 mg/m^2/dose PO bid; Start: 600 mg/m^2/dose PO bid ASAP w/in 24h post transplant; Max: 3 g/day; Alt: 750 mg PO bid for BSA 1.25-1.5 m^2; 1 g PO bid for BSA >1.5 m^2; Info: give on empty stomach; stable pts may take w/ food; do not open cap; do not cut/crush/chew tab

Liver transplant rejection prophylaxis

[3 mo and older]

Dose: 900 mg/m^2/dose PO bid; Start: 600 mg/m^2/dose PO bid ASAP w/in 24h post transplant; Max: 3 g/day; Alt: 750 mg PO bid for BSA 1.25-1.5 m^2; 1 g PO bid for BSA >1.5 m^2; Info: give on empty stomach; stable pts may take w/ food; do not open cap; do not cut/crush/chew tab

Renal dosing

CrCl <50: max 600 mg/m^2/day

HD: max 600 mg/m^2/day; no supplement after dialysis; PD: max 600 mg/m^2/day; no supplement

Hepatic dosing

[see below]

severe hepatic parenchymal disease: no adjustment; other hepatic impairment: not defined

SRC: NLM .