Celebrex Dosage

Generic name: celecoxib
Drug class: Cox-2 inhibitors

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  CAP: 50 mg, 100 mg, 200 mg, 400 mg

Osteoarthritis

[200 mg PO qd]
Alt: 100 mg PO bid; Info: use lowest effective dose, shortest effective tx duration; consider starting at 50% of lowest dose if poor CYP2C9 metabolizer; give w/ food if GI upset occurs

Rheumatoid arthritis

[100-200 mg PO bid]
Info: use lowest effective dose, shortest effective tx duration; consider starting at 50% of lowest dose if poor CYP2C9 metabolizer; give w/ food if GI upset occurs

Ankylosing spondylitis

[200 mg PO qd]
Max: 400 mg/day; Alt: 100 mg PO bid; Info: use lowest effective dose, shortest effective tx duration; may increase dose to 400 mg/day if no response after 6wk; consider D/C if no response to max dose after 6wk; consider starting at 50% of lowest dose if poor CYP2C9 metabolizer; give w/ food if GI upset occurs

Dysmenorrhea

[200 mg PO bid]
Start: 400 mg PO x1, may give additional 200 mg on day 1 if needed; Info: use lowest effective dose, shortest effective tx duration; consider starting at 50% of lowest dose if poor CYP2C9 metabolizer; give w/ food if GI upset occurs

Pain, acute

[200 mg PO bid]
Start: 400 mg PO x1, may give additional 200 mg on day 1 if needed; Info: use lowest effective dose, shortest effective tx duration; consider starting at 50% of lowest dose if poor CYP2C9 metabolizer; give w/ food if GI upset occurs

Renal dosing

[see below]
CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use; advanced renal dz: avoid use
HD/PD: avoid use

Hepatic dosing

[adjust dose amount]
Child-Pugh Class B: decrease dose 50%; Child-Pugh Class C: avoid use

Recommended Peds Dosing

Dosage forms:  CAP: 50 mg, 100 mg

Juvenile idiopathic arthritis

[2 yo and older, 10-25 kg]
Dose: 50 mg PO bid; Info: use lowest effective dose, shortest effective tx duration; consider alternative tx if poor CYP2C9 metabolizer; give w/ food if GI upset occurs
[2 yo and older, >25 kg]
Dose: 100 mg PO bid; Info: use lowest effective dose, shortest effective tx duration; consider alternative tx if poor CYP2C9 metabolizer; give w/ food if GI upset occurs

Renal dosing

CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use; advanced renal dz: avoid use
HD/PD: avoid use

Hepatic dosing

[adjust dose amount]
Child-Pugh Class B: decr. dose 50%; Child-Pugh Class C: avoid use

 

 

SRC: NLM .