Cefoxitin Dosage

Generic name: cefoxitin
Brand name: Mefoxin
Dosage forms: injectable powder for injection (10 g); intravenous powder for injection (1 g; 2 g); intravenous solution (1 g/50 mL-iso-osmotic dextrose; 2 g/50 mL-iso-osmotic dextrose)
Drug class: Second generation cephalosporins

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Infections, bacterial

[1-2 g IV q4-8h]

Max: 12 g/day; Info: dose, duration varies w/ infection type, severity

PID

[mild-moderate infection]

Dose: 2 g IM x1; Info: give w/ probenecid, doxycycline, and metronidazole; 1st-line agent

[severe infection]

Dose: 2 g IV q6h x14 days; Info: give w/ doxycycline; 1st-line agent; switch to PO regimen ASAP to complete course

Intra-abdominal infections

[1-2 g IV q4-8h]

Max: 12 g/day; Info: dose, duration varies w/ infection severity

Infection prophylaxis, surgical

[2 g IV x1]

Start: 60min preop; Info: may repeat dose in 2h

Infection prophylaxis, postcesarean

[2 g IV x1]

Start: 60min preop

Renal dosing

CrCl 30-50: give usual dose q8-12h; CrCl 10-29: give usual dose q12-24h; CrCl 5-9: 1-2 g x1, then 0.5-1 g q12-24h; CrCl <5: 1-2 g x1, then 0.5-1 g q24-48h

HD: 0.5-1 g q24-48h; give 1-2 g supplement after dialysis if next maint. dose not due right after dialysis; PD: 1 g q24h; no supplement

Hepatic dosing

[not defined]

Recommended Peds Dosing

Dosage forms:  INJ

infections, bacterial

[3 mo and older]

Dose: 80-160 mg/kg/day IV divided q4-6h; Max: 12 g/day; Info: dose, duration varies w/ infection type, severity

  Pelvic inflammatory disease

[mild-moderate infection, preadolescents >45 kg and adolescents]

Dose: 2 g IM x1; Info: give w/ probenecid, doxycycline, and metronidazole; 1st-line agent

[severe infection, preadolescents >45 kg and adolescents]

Dose: 2 g IV q6h x14 days; Info: give w/ doxycycline; 1st-line agent; switch to PO regimen ASAP to complete course

Infection prophylaxis, surgical

[1 yo and older]

Dose: 40 mg/kg/dose IV x1; Start: 60min preop; Info: may repeat in dose 2h

Renal dosing

[adjust dose frequency]

CrCl 30-50: give usual divided dose q8h; CrCl 10-29: give usual divided dose q12h; CrCl <10: give usual divided dose q24h

HD: give usual divided dose q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: give usual divided dose q24h; no supplement

Hepatic dosing

[not defined]

SRC: NLM .