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Cefepime Dosage

Generic name: cefepime (injection)
Brand names: Maxipime, Maxipime ADD-Vantage
Drug class: Fourth generation cephalosporins

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Adult Dosing

Dosage forms:  INJ

infections, bacterial

[1-2 g IV q8-12h]
Info: dose, duration varies w/ infection type, severity

pneumonia

[community-acquired]
Dose: 2 g IV q8h x7 days; Info: for inpatient tx; refer to IDSA guidelines
[hospital-acquired or ventilator-assoc.]
Dose: 2 g IV q8h x7 days; Info: may extend duration based on clinical response; refer to IDSA guidelines

febrile neutropenia

[2 g IV q8h until resolution of neutropenia]
Info: re-evaluate duration frequently if neutropenic >7 days

UTI

[mild-moderate]
Dose: 0.5-1 g IV q12h x7-10 days
[severe]
Dose: 2 g IV q12h x10 days

skin/skin structure infections, mod-severe uncomplicated

[2 g IV q12h x10 days]

intra-abdominal infections, complicated

[non-pseudomonal infections]
Dose: 2 g IV q12h x7-10 days; Info: give w/ metronidazole 500 mg PO/IV q6-8h
[pseudomonal infections]
Dose: 2 g IV q8h x7-10 days

Meningitis, healthcare-assoc.

[2 g IV q8h x10-14 days]
Info: may extend duration based on clinical and microbiologic response

Resp. infections, cystic fibrosis pts

[2 g IV q8h x14 days]

renal dosing

[if usual dose 500 mg q12h]
CrCl 11-60: 500 mg q24h; CrCl <11: 500 mg x1, then 250 mg q24h
HD: 1 g x1, then 500 mg q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 500 mg q48h; supplement not defined
[if usual dose 1 g q12h]
CrCl 30-60: 1 g q24h; CrCl 11-29: 1 g x1, then 500 mg q24h; CrCl <11: 1 g x1, then 250 mg q24h
HD: 1 g x1, then 500 mg q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 1 g q48h; supplement not defined
[if usual dose 2 g q12h]
CrCl 30-60: 2 g q24h; CrCl 11-29: 2 g x1, then 1 g q24h; CrCl <11: 2 g x1, then 500 mg q24h
HD: 1 g x1, then 500 mg q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 2 g q48h; supplement not defined
[if usual dose 2 g q8h]
CrCl 30-60: 2 g q12h; CrCl 11-29: 2 g q24h; CrCl <11: 2 g x1, then 1 g q24h
HD: 1 g q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 2 g q48h; supplement not defined

hepatic dosing

[no adjustment]

 

 

 

SRC: NLM .

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