Caspofungin Dosage
Generic name: caspofungin
Brand name: Cancidas
Dosage form: intravenous powder for injection (50 mg; 70 mg)
Drug class: Echinocandins
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
Candidemia
- [50 mg IV q24h]
- Start: 70 mg IV x1 on day 1; Max: 70 mg/day; Info: cont. x14 days after last positive culture
Candidiasis
- [esophageal]
- Dose: 50 mg IV q24h; Start: 70 mg IV x1 on day 1; Info: cont. x7-14 days after sx resolution
- [intra-abdominal, peritoneal, pleural space]
- Dose: 50 mg IV q24h; Start: 70 mg IV x1 on day 1; Max: 70 mg/day; Info: cont. x14 days after last positive culture
- [*oropharyngeal]
- Dose: 50 mg IV q24h; Start: 70 mg IV x1 on day 1; Info: for fluconazole-refractory dz
- [*systemic]
- Dose: 50-70 mg IV q24h; Info: dose, duration vary by indication
Febrile neutropenia
- [50 mg IV q24h]
- Start: 70 mg IV on day 1; Max: 70 mg/day; Info: cont. until resolution of neutropenia, or if fungal infection found cont. x14 days minimum or x7 days after resolution of neutropenia and clinical sx
Aspergillosis, refractory
- [50 mg IV q24h]
- Start: 70 mg IV x1 on day 1; Max: 70 mg/day; Info: tx duration varies
Endocarditis, candidal
- [150 mg IV q24h]
- Info: for native valve endocarditis; not 1st-line agent; refer to IDSA and AHA guidelines
Renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
Hepatic dosing
[adjust dose amount]
Child-Pugh Class B: 70 mg x1 on day 1 if indicated, then give 35 mg qd; Child-Pugh Class C: not defined
Recommended Peds Dosing
Dosage forms: INJ
Candidemia
[3 mo-17 yo]
Dose: 50 mg/m^2/dose IV q24h; Start: 70 mg/m^2 on day 1; Max: 70 mg/day; Info: cont. x14 days after last positive culture
Candidiasis
[esophageal, 3 mo-17 yo]
Dose: 50 mg/m^2/dose IV q24h; Start: 70 mg/m^2 on day 1; Max: 70 mg/day; Info: cont. x7-14 days after sx resolution
[intra-abdominal, peritoneal, pleural space, 3 mo-17 yo]
Dose: 50 mg/m^2/dose IV q24h; Start: 70 mg/m^2 on day 1; Max: 70 mg/day; Info: cont. x14 days after last positive culture
Febrile neutropenia
[3 mo-17 yo]
Dose: 50 mg/m^2/dose IV q24h; Start: 70 mg/m^2 on day 1; Max: 70 mg/day; Info: cont. until resolution of neutropenia, or if fungal infection found cont. x14 days minimum or x7 days after resolution of neutropenia and clinical sx
Aspergillosis, refractory
[3 mo-17 yo]
Dose: 50 mg/m^2/dose IV q24h; Start: 70 mg/m^2 on day 1; Max: 70 mg/day; Info: tx duration varies
Renal dosing
[no adjustment]
renal impairment: no adjustment
HD/PD: no adjustment; no supplement
Hepatic dosing
[not defined]
hepatic impairment: consider adult hepatic dosing for guidance
SRC: NLM .