Carospir Dosage

Generic name: spironolactone
Brand names: Aldactone, CaroSpir
Drug classes: Aldosterone receptor antagonists, Potassium-sparing diuretics

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  SUSP: 25 mg per 5 mL

Special Note

[formulation clarification]

Info: spironolactone susp and tabs not bioequivalent; reassess dose if switching between products; susp doses >100 mg may result in higher than expected conc; use tab form for doses >100 mg

Heart failure w/ reduced ejection fraction, NYHA Class III-IV

[20 mg-37.5 mg PO qd]

Info: may decr. dose to 25 mg qod if hyperkalemia; hold if K >5 mEq/L

HTN

[20-75 mg/day PO divided qd-bid]

Max: 75 mg/day; Info: may adjust dose q2wk

Edema, cirrhosis-assoc.

[75-100 mg/day PO divided qd-bid]

Max: 100 mg/day; Info: if given as monotherapy, may incr. dose after 5 days

Renal dosing

[heart failure w/ reduced ejection fraction, NYHA Class III-IV]

eGFR 30-50: consider starting 10 mg qd; eGFR <30: avoid use

HD/PD: not defined

[all other indications]

CrCl <30: avoid use in pts 65 yo and older

HD/PD: not defined

Hepatic dosing

[not defined]

hepatic impairment: caution advised

SRC: NLM .