Carbaglu Dosage

Generic name: carglumic acid
Drug class: Miscellaneous uncategorized agents

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  DISPERSE TAB: 200 mg

Acute hyperammonemia, N-acetylglutamate synthase deficiency-related

[100-250 mg/kg/day PO/NG/GT divided bid-qid]
Info: for adjunct tx; round dose to nearest 100 mg; adjust dose based on plasma ammonia levels; give before meals

Chronic hyperammonemia, N-acetylglutamate synthase deficiency-related

[10-100 mg/kg/day PO/NG/GT divided bid-qid]
Info: round dose to nearest 100 mg; adjust dose based on plasma ammonia levels; give before meals

Acute hyperammonemia, propionic acidemia-related

[3300 mg/m^2/day PO/NG/GT divided q12h]
Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals

Acute hyperammonemia, methylmalonic acidemia-related

[3300 mg/m^2/day PO/NG/GT divided q12h]
Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals

Renal dosing

[acute hyperammonemia, N-acetylglutamate synthase deficiency-related]
eGFR 30-59: 50-125 mg/kg/day divided bid-qid; eGFR <30: 15-60 mg/kg/day divided bid-qid; Info: round dose to nearest 50 mg
HD/PD: not defined
[chronic hyperammonemia, N-acetylglutamate synthase deficiency-related]
eGFR 30-59: 5-50 mg/kg/day divided bid-qid; eGFR <30: 2-25 mg/kg/day divided bid-qid; Info: round dose to nearest 50 mg
HD/PD: not defined
[acute hyperammonemia, propionic acidemia-related]
eGFR 30-59: 1700 mg/m^2/day divided q12h; eGFR <30: 550 mg/m^2/day divided q12h; Info: round dose up to next 50 mg
HD/PD: not defined
[acute hyperammonemia, methylmalonic acidemia-related]
eGFR 30-59: 1700 mg/m^2/day divided q12h; eGFR <30: 550 mg/m^2/day divided q12h; Info: round dose up to next 50 mg
HD/PD: not defined

Hepatic dosing

[not defined]

Recommended Peds Dosing

Dosage forms:  DISPERSE TAB: 200 mg

Acute hyperammonemia, N-acetylglutamate synthase deficiency-related

[100-250 mg/kg/day PO/NG/GT divided bid-qid]
Info: for adjunct tx; round dose to nearest 100 mg; adjust dose based on plasma ammonia levels; give before meals

Chronic hyperammonemia, N-acetylglutamate synthase deficiency-related

[10-100 mg/kg/day PO/NG/GT divided bid-qid]
Info: round dose to nearest 100 mg; adjust dose based on plasma ammonia levels; give before meals

Acute hyperammonemia, propionic acidemia-related

[<15 kg]
Dose: 150 mg/kg/day PO/NG/GT divided q12h; Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals
[>15 kg]
Dose: 3300 mg/m^2/day PO/NG/GT divided q12h; Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals

Acute hyperammonemia, methylmalonic acidemia-related

[<15 kg]
Dose: 150 mg/kg/day PO/NG/GT divided q12h; Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals
[>15 kg]
Dose: 3300 mg/m^2/day PO/NG/GT divided q12h; Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals

Renal dosing

[acute hyperammonemia, N-acetylglutamate synthase deficiency-related]
eGFR 30-59: 50-125 mg/kg/day divided bid-qid; eGFR <30: 15-60 mg/kg/day divided bid-qid; Info: round dose to nearest 50 mg
HD/PD: not defined
[chronic hyperammonemia, N-acetylglutamate synthase deficiency-related]
eGFR 30-59: 5-50 mg/kg/day divided bid-qid; eGFR <30: 2-25 mg/kg/day divided bid-qid; Info: round dose to nearest 50 mg
HD/PD: not defined
[acute hyperammonemia, propionic acidemia-related, <15 kg]
eGFR 30-59: 75 mg/kg/day divided q12h; eGFR <30: 25 mg/kg/day divided q12h; Info: round dose up to next 50 mg
HD/PD: not defined
[acute hyperammonemia, propionic acidemia-related, >15 kg]
eGFR 30-59: 1700 mg/m^2/day divided q12h; eGFR <30: 550 mg/m^2/day divided q12h; Info: round dose up to next 50 mg
HD/PD: not defined
[acute hyperammonemia, methylmalonic acidemia-related, <15 kg]
eGFR 30-59: 75 mg/kg/day divided q12h; eGFR <30: 25 mg/kg/day divided q12h; Info: round dose up to next 50 mg
HD/PD: not defined
[acute hyperammonemia, methylmalonic acidemia-related, >15 kg]
eGFR 30-59: 1700 mg/m^2/day divided q12h; eGFR <30: 550 mg/m^2/day divided q12h; Info: round dose up to next 50 mg
HD/PD: not defined

Hepatic dosing

[not defined]

 

 

SRC: NLM .