Bupivacaine Dosage

Generic name: bupivacaine
Brand names: Marcaine HCl, Marcaine Spinal, Sensorcaine, Sensorcaine-MPF, Sensorcaine-MPF Spinal, Xaracoll
Drug class: Local injectable anesthetics

Medically reviewed by A Ras MD.

Adult Dosing

Dosage forms: INJ (0.25%): 2.5 mg per mL; INJ (0.5%): 5 mg per mL; INJ (0.75%): 7.5 mg per mL; INJ (0.75% hyperbaric): 7.5 mg per mL

Special Note

[formulation clarification]: Info: not interchangeable w/ bupivacaine liposomal; do not substitute on a mg to mg basis; some concentrations methylparaben-free (MPF)

Local anesthesia

[infiltration]: Dose: up to 175 mg (0.25% conc.) via infiltration x1; Max: 400 mg/24h; Info: may repeat dose q3h prn; onset 2-10min, peak 30-45min, duration 3-6h

Regional anesthesia

Peripheral nerve block

Retrobulbar block

Sympathetic nerve block

Caudal block

Lumbar block

Spinal anesthesia

lower abdominal procedures

Dose: 12 mg (0.75% hyperbaric) intrathecally x1; Info: onset <1min, peak 15min, duration 3-6h

lower extremity or perineural procedures
- Dose: 7.5 mg (0.75% hyperbaric) intrathecally x1; Info: onset <1min, peak 15min, duration 3-6h
obstetrical procedures, vaginal delivery
- Dose: 6 mg (0.75% hyperbaric) intrathecally x1; Info: onset <1min, peak 15min, duration 3-6h
Obstetrical procedures, cesarean section
- Dose: 7.5-10.5 mg (0.75% hyperbaric) intrathecally x1; Info: onset <1min, peak 15min, duration 3-6h

Renal dosing

renal impairment: not defined, caution advised

HD/PD: not defined

Hepatic dosing

mild impairment: not defined, caution advised; moderate-severe impairment: consider decr. dose

SRC: NLM .

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