Bosutinib Dosage

Adult Dosing

Dosage forms:  TAB: 100 mg, 400 mg, 500 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

Ph-positive CML

[chronic phase, newly diagnosed dz]

Dose: 400 mg PO qd; Info: may incr. dose to 600 mg PO qd; give w/ food; do not cut/crush/chew tab

[chronic phase, resistant or intolerant dz]

Dose: 500 mg PO qd; Info: may incr. dose to 600 mg PO qd; give w/ food; do not cut/crush/chew tab

[accelerated phase or blast phase, resistant or intolerant dz]

Dose: 500 mg PO qd; Info: may incr. dose to 600 mg PO qd; give w/ food; do not cut/crush/chew tab

Renal dosing

[newly diagnosed dz]

CrCl 30-50: 300 mg qd; CrCl <30: 200 mg qd

HD/PD: not defined

[resistant or intolerant dz]

CrCl 30-50: 400 mg qd; CrCl <30: 300 mg qd

HD/PD: not defined

Hepatic dosing

[adjust dose amount]

Child-Pugh Class A, B, or C: 200 mg qd

SRC: NLM .