BeneFix Dosage

Generic name: coagulation factor IX
Brand names: AlphaNine SD, Alprolix, BeneFIXIdelvionIxinity
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by  A Ras MD.

 

Adult Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]
Info: 1 unit/kg will incr. factor IX level approx. 0.8%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

Hemophilia B

[bleeding episode, minor]
Dose: individualize dose IV q12-24h x1-2 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 20-30%
[bleeding episode, moderate]
Dose: individualize dose IV q12-24h x2-7 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 25-50%
[bleeding episode, major]
Dose: individualize dose IV q12-24h x7-10 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 50-100%
[bleeding prophylaxis, minor surgery]
Dose: individualize dose IV x1 preop, then cont. q12-24h x1-2 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 20-30%
[bleeding prophylaxis, moderate surgery]
Dose: individualize dose IV x1 preop, then cont. q12-24h x2-7 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 25-50%
[bleeding prophylaxis, major surgery]
Dose: individualize dose IV x1 preop, then cont. q12-24h x7-10 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 50-100%
[bleeding prophylaxis, routine]
Dose: 100 units/kg/dose IV qwk; Info: adjust dose based on clinical response

Renal dosing

renal impairment: not defined
HD/PD: not defined

Hepatic dosing

hepatic impairment: caution advised

 

SRC: NLM .