Bebulin Dosage

Generic name: factor IX complex
Brand names: Bebulin, Bebulin VH, Profilnine SD

Medically reviewed by  A Ras MD.

Adult Dosing

Dosage forms:  INJ

Brand Name Changed in US

[previously Bebulin VH]

Hemophilia B

[bleeding episode, minor]

Dose: individualize dose IV x1; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.25] where desired factor IX level 20-40%; 1 unit/kg will incr. factor IX level approx. 0.8%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, moderate]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.25] where desired factor IX level 30-60%; 1 unit/kg will incr. factor IX level approx. 0.8%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, major]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.25] where desired factor IX level 60-80%; 1 unit/kg will incr. factor IX level approx. 0.8%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.25] where desired factor IX level 30-60%; 1 unit/kg will incr. factor IX level approx. 0.8%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.25] where desired factor IX level 60-80%; 1 unit/kg will incr. factor IX level approx. 0.8%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, long-term tx]

Dose: 20-30 units/kg/dose IV 1-2x/wk; Info: individualize dose; 1 unit/kg will incr. factor IX level approx. 0.8%

Renal dosing

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

hepatic impairment: caution advised

SRC: NLM .