Baraclude Dosage

Generic name: entecavir
Drug class: Nucleoside reverse transcriptase inhibitors (NRTIs)

Medically reviewed by  A Ras MD.

Adult Dosing

Dosage forms:  TAB: 0.5 mg, 1 mg; SOL: 0.05 mg per mL

Hepatitis B infection, chronic

[compensated liver dz, nucleoside-naive pts]

Dose: 0.5 mg PO qd; Info: give 2h before or after meal

[compensated liver dz, nucleoside-refractory pts]

Dose: 1 mg PO qd; Info: for lamivudine-refractory or known lamivudine or telbivudine resistance substitutions; give 2h before or after meal

[decompensated liver dz]

Dose: 1 mg PO qd; Info: give 2h before or after meal

Renal dosing

[compensated liver dz, nucleoside-naive pts]

CrCl 30-49: 0.25 mg solution qd or 0.5 mg q48h; CrCl 10-29: 0.15 mg solution qd or 0.5 mg q72h; CrCl <10: 0.05 mg solution qd or 0.5 mg qwk

HD: 0.05 mg solution qd or 0.5 mg qwk, on dialysis days admin. after dialysis; no supplement; PD: 0.05 mg solution qd or 0.5 mg qwk; no supplement

[compensated liver dz, nucleoside-refractory pts]

CrCl 30-49: 0.5 mg qd or 1 mg q48h; CrCl 10-29: 0.3 mg solution qd or 1 mg q72h; CrCl <10: 0.1 mg solution qd or 1 mg qwk

HD: 0.1 mg solution qd or 1 mg qwk, on dialysis days admin. after dialysis; no supplement; PD: 0.1 mg solution qd or 1 mg qwk; no supplement

[decompensated liver dz]

CrCl 30-49: 0.5 mg qd or 1 mg q48h; CrCl 10-29: 0.3 mg solution qd or 1 mg q72h; CrCl <10: 0.1 mg solution qd or 1 mg qwk

HD: 0.1 mg solution qd or 1 mg qwk, on dialysis days admin. after dialysis; no supplement; PD: 0.1 mg solution qd or 1 mg qwk; no supplement

Hepatic dosing

[no adjustment]

SRC: NLM .