Generical Name: Brigatinib
Brand Name: Alunbrig
Drug class: Multikinase inhibitors
Alunbrig (brigatinib) is a treatment for cancer which inhibits the spread and growth of cancerous cells within the body.
Alunbrig can be used to treat non-small-cell lung cancer that can have spread to various areas within the human organs (metastatic).
Alunbrig is only used when cancer you are suffering from has a specific Genetic signpost (an unusual “ALK” gene). The doctor will check your body for the gene.¶
Alunbrig could result in serious side effects such as lung issues vision issues, hypertension, elevated blood sugar, extremely slow heartbeats, and muscle damage or pancreatitis.
Contact your physician immediately if you experience any symptoms of a side effect, like severe headache, disorientation, feeling lightheaded blurred vision, noticing lights flashing as “floaters” in your vision and increased thirst or urination nausea, stomach pain that is spreading to your back, not able to explain muscles or muscle weakness, cough, fever and chest pain, difficulty breathing, extremely slow heartbeats or feeling like you may be passing out.
Before you start taking this medicine, make sure to consult your doctor.
You shouldn’t make use of Alunbrig If you are allergic to Brigatinib.
To ensure that Alunbrig is suitable for you, inform your doctor if previously had:
- Lung disease or breathing issues;
- Slow heart rate (Bradycardia)
- high blood pressure
- vision issues;
- insulin resistance or glucose intolerance
- problems with the pancreas;
- liver disease liver disease
- kidney disease (or those who are taking dialysis).
You might need to undergo an unfavorable pregnancy test prior to commencing this treatment.
Brigatinib may cause harm to a baby who is not yet born when either the father or mother is taking the medicine.
- If you’re pregnant, do not use this medication if you’re expecting. Alunbrig could reduce the effectiveness of hormonal birth control effective, which includes Birth control pills, injectables implants, patches for skin, or vaginal rings. To keep from becoming pregnant while taking Alunbrig, use efficient non-hormonal birth control like IUDs. (IUD). Be sure to avoid becoming pregnant for at least four months following the last dose.
- If you’re male, use condoms or other birth control options that block the birth process in the event that your partners are able to get pregnant. Continue using condoms for at least three months following the last dose.
- Inform your doctor immediately when you notice a pregnancy when one of the mothers or father is taking Brigatinib.
Alunbrig could alter the fertility (ability to bear children) for men. It is, however, it is important to utilize birth control to stop pregnancy as brigatinib may cause harm to a baby who is not yet born.
It is not recommended to breastfeed while taking this medicine and for at least one week following the last dose.
How to take Alunbrig?
Follow the exact dosage of Alunbrig prescribed by your physician. Follow the instructions on your prescription label, and go through all the medication guides or instructions sheets. Your doctor may alter your dosage.
Alunbrig is typically consumed every day, either in combination with or without meals.
Take the tablet in one swallow and don’t crush, chew or break it.
If you have a vomiting reaction within a few hours of taking Alunbrig don’t take a second dose. Keep your normal routine.
Your blood pressure needs to be monitored frequently.
It is not recommended to stop taking this medication unless your physician advises you to.
Place in a cool, dry place far from heat and moisture.
Usual Adult Dose for Non-Small Cell Lung Cancer:
Initial Dose: 90mg every day during the initial 7 days
Maintenance Dose: If the initial dose is acceptable during the initial 7 days gradually increase to 180 mg taken orally every day.
The duration of therapy is until the progression of the disease or unacceptably toxic
Use: Treatment for patients suffering from anaplastic lymphoma kinase (ALK)-positive metastatic non-small-cell lung cancer (NSCLC) who have advanced on or are not tolerant to crizotinib.
If I do not take a dose?
Do not miss the missed dose, and take the next dose at the normal time. Avoid using two doses at the same time.
How do I react if consume too much?
Get medical attention immediately or contact for help at the Poison Help line at 1-800-222-1222.
What should you be aware of to
Grapefruit can interact with brigatinib , and can lead to undesirable reactions. Do not use grapefruit-related products.
The medicine can cause blurred vision and could affect your reaction time. Avoid driving or engaging in hazardous activities until you are aware of what effects this medicine can have on your vision.
Alunbrig side effects
See a doctor immediately If you are experiencing symptoms that you are experiencing an allergic reaction Alunbrig: hives; difficulty breathing or swelling of your lips, face, or tongue.
Consult your physician immediately If you are suffering from:
- lung issues such as coughing, difficulty breathing discomfort in the chest, and fever
- vision issues blurred vision, double vision, increased sensitivity light, experiencing flashes of light, or “floaters” in your vision;
- High blood pressure – extreme headache, pounding your ears or neck dizziness, headache;
- blood sugar levels are high. – more thirst, increased urination nausea, hunger, breath smell as well as confusion, weakness, and weakness.
- heart issues Very slow heartbeats and the feeling that you could faint;
- muscle issues Unexplained muscle weakness or pain; or
- pancreatitis Upper stomach pain (worse after eating and can extend onto your back) nausea, vomiting, and weight loss.
The treatment for cancer may be delayed or discontinued permanently when you experience certain adverse side consequences.
Common Alunbrig side effects can be:
- nausea, vomiting, diarrhea;
- elevated blood pressure
- trouble breathing
- muscle pain;
- headaches migraine
- Feeling exhausted.
This isn’t a complete list of all side effects. other effects may also be experienced. Consult your physician to seek medical advice on the effects. You can report symptoms to FDA at 1-800-FDA-1088.
What other medications can alter the effects of Alunbrig?
It is sometimes not recommended to take certain medicines in conjunction. Certain drugs may affect the blood levels from other medications you are taking, which could create side effects or render the medication less effective.
A variety of drugs interfere with Brigatinib. This includes prescription and over-the-counter supplements, vitamins, as well as herbal supplements. There are not all interactions mentioned in this article. Inform your doctor of all the medications you are currently taking and any medication you begin or stop taking.
Always consult your doctor to make sure the information presented on this page is applicable to your specific situation.