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ADRUCIL SIDE EFFECTS

  • Generic Name: fluorouracil injection
  • Brand Name: Adrucil
  • Drug Class: Antineoplastics, Antimetabolite
Last updated on MDtodate: 10/6/2022

SIDE EFFECTS

The following adverse reactions are discussed in more detail in other sections of the labeling:

  • Increased risk of serious or fatal adverse reactions in patients with low or absent dipyrimidine dehydrogenase activity
  • Cardiotoxicity
  • Hyperammonemic encephalopathy
  • Neurologic toxicity [
  • Diarrhea
  • Palmar-plantar erythrodysesthesia (hand-foot syndrome)
  • Myelosuppression
  • Mucositis
  • Increased risk of elevated INR when administrated with warfarin

Postmarketing Experience

The following adverse reactions have been identified during postapproval use of fluorouracil. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Hematologic: pancytopenia

Gastrointestinal: gastrointestinal ulceration, nausea, vomiting

Allergic Reactions: anaphylaxis and generalized allergic reactions

Neurologic: nystagmus, headache

Dermatologic: dry skin; fissuring; photosensitivity, as manifested by erythema or increased pigmentation of the skin; vein pigmentation

Ophthalmic: lacrimal duct stenosis, visual changes, lacrimation, photophobia

Psychiatric: euphoria

Miscellaneous: thrombophlebitis, epistaxis, nail changes (including loss of nails)

 

SRC: NLM .

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