Cisatracurium Dosage

Generic name: cisatracurium
Brand name: Nimbex
Dosage form: intravenous solution (10 mg/mL; 2 mg/mL; 20 mg/10 mL)
Drug class: Neuromuscular blocking agents

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  INJ

Neuromuscular blockade induction

[150-200 mcg/kg/dose IV x1]

Info: onset 1.5-2min, duration 55-61min (intermediate-acting); max initial bolus 20 mcg/kg/dose if neuromuscular disease; consider extended interval between dose admin. and intubation by at least 1min in elderly pts

Neuromuscular blockade maintenance

[intermittent IV]

Dose: 30 mcg/kg/dose IV q20min prn; Start: 40-60min after 150 mcg/kg induction dose, 50-60min after 200 mcg/kg induction dose

[continuous IV]

Dose: 1-2 mcg/kg/min IV; Start: 3 mcg/kg/min IV after spontaneous recovery from induction dose; Info: rates may vary widely between 0.5-10 mcg/kg/min; decrease. rate 30-40% if under isoflurane or enflurane anesthesia, 50% if undergoing CABG w/ induced hypothermia

Renal dosing

renal impairment: not defined; Info: consider the extended interval between dose admin. and intubation by at least 1min if end-stage renal disease

HD/PD: not defined

Hepatic dosing

[not defined]

end-stage hepatic disease: onset 1min faster vs. healthy controls

Recommended Peds Dosing

Dosage forms:  INJ

Neuromuscular blockade induction

[1-23 mo]

Dose: 150 mcg/kg/dose IV x1; Info: onset 2min, duration 43min (intermediate-acting); max initial bolus 20 mcg/kg/dose if neuromuscular dz

[2-12 yo]

Dose: 100-150 mcg/kg/dose IV x1; Info: onset 2.8-3min, duration 28-36min (intermediate-acting); max initial bolus 20 mcg/kg/dose if neuromuscular dz

[>12 yo]

Dose: 150-200 mcg/kg/dose IV x1; Info: onset 1.5-2min, duration 55-61min (intermediate-acting); max initial bolus 20 mcg/kg/dose if neuromuscular dz

Neuromuscular blockade maintenance

[2 yo and older]

Dose: 1-2 mcg/kg/min IV; Start: 3 mcg/kg/min IV after spontaneous recovery from induction dose; Info: rates may vary widely between 0.5-10 mcg/kg/min; decrease. rate 30-40% if under isoflurane or enflurane anesthesia

Renal dosing

[see below]

renal impairment: not defined; Info: consider the extended interval between dose admin. and intubation by at least 1min if end-stage renal disease

HD/PD: not defined

Hepatic dosing

[not defined]

end-stage hepatic ddisease: onset 1min faster vs. healthy controls

 

SRC: NLM .